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강직성 척추염 환자에서 Infliximab 투여 후 헤노흐-쇤라인 자색반 1예

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Author(s)
정우진남윤정이승근김지민송마가렛김문범김근태
Keimyung Author(s)
Chung, Woo JinKim, Ji Min
Department
Dept. of Internal Medicine (내과학)
Journal Title
대한내과학회지
Issued Date
2013
Volume
84
Issue
5
Abstract
Tumor necrosis factor alpha (TNF-α) inhibitors are used widely to treat patients with active rheumatoid arthritis and ankylosing
spondylitis (AS). Although various cutaneous reactions can occur as side effects of TNF-α inhibitors, systemic vasculitis requiring
withdrawal of the agent and immunosuppressive drugs is rare. A 59-year-old male with AS who had been treated with infliximab for
60 months visited us with complaints of palpable purpura on both legs and severe abdominal pain. Abdominal computed tomography
showed diffuse wall thickening of the proximal jejunum and ileum and a skin biopsy revealed leukocytoclastic vasculitis. The
patient was diagnosed with Henoch-Schönlein purpura (HSP). Infliximab was discontinued and systemic steroid therapy at 0.5
mg/kg resulted in prompt resolution of the HSP. Here, we report the first case of HSP in a patient with AS after infliximab treatment.
(Korean J Med 2013;84:764-768)
Keywords: Ankylosing spondylitis, Henoch-Schönlein purpura, Tumor necrosis factor-alpha inhibitor
저자들은 강직성 척추염 환자에서 infliximab을 사용한 이
후 발생한 헤노흐-쇤라인 자색반을 진단하고 약제 중단 및
스테로이드 요법으로 재발 없이 성공적으로 치료하였기에
문헌고찰과 함께 보고하는 바이다.
중심 단어: 강직성 척추염; 헤노흐-쇤라인 자색반; 인플릭
시맵
Alternative Title
Henoch-Shönlein Purpura in a Patient with Ankylosing Spondylitis after Infliximab Therapy
Keimyung Author(s)(Kor)
정우진
김지민
Publisher
School of Medicine
Citation
정우진 et al. (2013). 강직성 척추염 환자에서 Infliximab 투여 후 헤노흐-쇤라인 자색반 1예. 대한내과학회지, 84(5), 764–768. doi: 10.3904/kjm.2013.84.5.764
Type
Article
ISSN
1738-9364
DOI
10.3904/kjm.2013.84.5.764
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37726
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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