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성인 특발성 신증후군의 임상적 관찰

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Author(s)
김현철최찬오정태훈서영숙박성배박관규이상숙
Keimyung Author(s)
Kim, Hyun ChulPark, Sung BaePark, Kwan KyuLee, Sang Sook
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Journal Title
대한내과학회지
Issued Date
1991
Volume
40
Issue
4
Abstract
A clinical observation was made on 150 adult patients with idiopathic nephrotic syndrome according to their histological types classified by light microscopic findings at Keimyung University Hospital for the past 6 years.

The majority of patients with nephrotic syndrome were young (mean age, 29.6), and the 80% of patients were less then 40 years old. The male-to-female ratio was 2.2:1 with male predominance.

Histopathologic findings of 150 renal biopsy tissues were classified into minimal change nephrotic syndrome (MCNS) 58%, focal glomerulosclerosis (16.7%), mem-branoproliferativeglomerulonephritis (10.0%), membranous nephropathy (9.3%), mesangial proliferative glomerulonephritis (3.3%), and chronic glomerulonephritis (2.7%).

The incidence of hypoalbuminemia and hypercholesterolemia was more frequent in MCNS than in other histological types. Microscopic hematuria (RBCi3 in HPF) was seen in 45% of MCNS and in 66% of other histological types. The time interval between the onset of symptoms and diagnosis was shorter in MCNS than in other histological types.

The average age at onset was youngest in MCNS (mean age, 25) and oldest in membranous nephropathy Microscopic hematuria, renal insufficiency, and hypocomplementemia was most frequently seen in membranoproliferative glomerulonephritis than in other histological types, and hypertension was most frequent in membranous nephropathy.

In reaction to steroid therapy, the highest response rate was seen in MCNS, which showed complete remission in 54%, partial remission in 21%, and no response in 24%. Meanwhile, those with other histological types showed only partial remission or no response at all. Sixty-six percent of patients with with MCNS experi-

enced remission in 4 weeks, and 93% of patients with MCNS went into remission within 8 weeks of steroid therapy. Major side effects of steroid therapy were Cushingoid appearance (27.1%), facial ance (10.2%), diabetes mellitus (8.5%), and peptic ulcer (3.4%), in decreasing order of frequency.

With cyclophosphamide therapy, complete remission was obtainded in 60% of patients with MCNS, while 20% of patients with MCNS had partial remission. In contrast, none of the patients with other histological types except mesangial proliferative glomerulonephritis showed complete remission.

During the follow-up period, the majority of patients with MCNS were in complete or partial remission, wherease patients with other histological types showed persistent nephrotic syndrome. Five patients died within 2 years after diagnosis, 2 from miliary tuberculosis and the other 3 from uremia, diabetic ketoacidosis, and suicide. Key Words: Nephrotic syndome, Steroid therapy. Cyclophosphamide
Alternative Title
Clinical Studies on the Adult Idiopathic Nephrotic Syndrome in Korea
Keimyung Author(s)(Kor)
김현철
박성배
박관규
이상숙
Publisher
School of Medicine
Citation
김현철 et al. (1991). 성인 특발성 신증후군의 임상적 관찰. 대한내과학회지, 40(4), 516–525.
Type
Article
ISSN
1226-329x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37765
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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