최신 콜레스테롤 치료 가이드라인: 2013 ACC/AHA Guideline and 2014 NICE Draft Guideline
- Author(s)
- 허승호
- Keimyung Author(s)
- Hur, Seung Ho
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- 대한내과학회지
- Issued Date
- 2014
- Volume
- 87
- Issue
- 2
- Abstract
- Low-density lipoprotein (LDL) cholesterol plays a major role in the development and progression of atherosclerosis. Numerous
studies have demonstrated that the management of cholesterol, mainly treated with statins, can reduce LDL cholesterol levels and
improve clinical outcomes. The American College of Cardiology (ACC) and American Heart Association (AHA) recently released
new guidelines that included the new concept of atherosclerotic cardiovascular disease (ASCVD) and pooled cohort equations for
estimation of the 10-year ASCVD risk in individuals. Conversely, the draft National Institute for Health and Care Excellence
(NICE) guideline is currently being updated following its publication in 2008. This draft guidance introduced the QRISK2 risk
assessment tool for the risk of development of cardiovascular disease in the next 10 years and combined with cost effectiveness.
Importantly, both guidelines suggested moderate- to high-intensity statin therapy for the primary and secondary prevention of
cardiovascular disease. In this article, we focus on the new risk assessments and recommendations for the use of lipid-lowering
therapy in each guideline. (Korean J Med 2014;87:142-150)
Keywords: Guideline; Cholesterol; Statins; HMG-CoA; Cardiovascular diseases
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