항암화학요법으로 장기 생존을 보인 원발성 난소 소세포암 1예

Abstract

Ovarian small cell carcinoma is a rare type of ovarian carcinoma with a poor prognosis.The hypercalcemic type is a tumor of unknown histogenesis, and small cell carcinoma of the pulmonary type may be a component of a typical ovarian surface epithelial-stromal tumor. We experienced a case of primary ovarian small cell carcinoma and lung metastasis. The patient was a 65-year old woman who complained of rectal heaviness. The chest x-ray and chest CT scan revealed multiple pulmonary metastases. Abdominal MRI showed a well defined heterogenous solid mass with central necrosis arising from the right ovary and hydronephrosis of the right kidney. Biopsy of the ovarian mass showed small cell carcinoma of the pulmonary type. After 4 cycles of cisplatin (80 mg/m2, on day 1, iv), etoposide (100 mg/m2, on day 1 to 3, iv), the patient achieved a complete response. The follow up chest CT scan 5 years after treatment revealed no evidence of disease. We report here in a case of primary small cell carcinoma of the ovary with lung metastasis and we include a review of the literature.(Korean J Med 72:563-567, 2007) Key Words : Carcinoma, Ovary

저자들은 65세 여자 환자가 직장 중압감을 주소로 내 원하여 복부 단층 촬영상에서 난소에 종괴가 확인되어 시행한 조직 검사상 소세포암으로 판명되었으며, 4차례 의 cisplatin+etoposide 복합항암화학 요법 시행 후 완전 관해된 뒤 약 5년간 재발의 증거가 없는 경과가 매우 양 호한 진행 병기의 원발성 난소 소세포암 1예를 경험하였 기에 이에 문헌고찰과 함께 보고하는 바이다. 중심 단어 : 원발성 난소 소세포암