계명대학교 의학도서관 Repository

Cuprophane 투석막이 혈장보체 활성화와 β₂-microglobulin제거율에 미치는 영향

Metadata Downloads
Author(s)
배장호박근용박성배김현철
Keimyung Author(s)
Park, Keun YongPark, Sung BaeKim, Hyun Chul
Department
Dept. of Internal Medicine (내과학)
Journal Title
대한신장학회지
Issued Date
1994
Volume
13
Issue
3
Abstract
It has long been known that complement activation plays a pivotal role in the pathogensis of hemodialysis-induced leukopenia through the release of anaphylatoxins, C3a and C5a. Efficient removal of β₂­microglobulin in end-stage renal failure patients is a continuing preoccupation, as the incidence and severity of dialysis-associated amyloidosis are increasing.

The present study was conducted to evaluate both the biocompatibility profile and the capacity to remove β₂­microglobulin during hemodialysis using a cuprophane membrane.

In this study, plasma C3a, C5a, leukocytes counts, and serum β₂­microglobulin were measured in 10 stable patients with chronic renal failure, undergoing maintenance hemodialysis with cuprophane membrane. The plasma levels of C3a desArg were significantly elevated at the first 15 minutes after initation of hemodialysis, and then slowly returned to basal level at 4 hours. However, the plasma levels of C5a desArg did not show any significant change during hemodialysis. Leukocyte counts decreased significantly from 6396±1811/mm3 before dialysis to 1986±742/mm3 at 15 minutes after initiation of hemodialysis (p<0.0005),and almost retured to predialysis values at 60 minutes after dialysis. There was a significant correlation between leukocyte counts and plasma C3a desArg levels at the first 15 minutes after initiation of hemodialysis (r=0.81’ p<0. 005) and during hemodialysis (r =0.32,p <0.05). Our study showed a 3.3% increase of serum ft-microglobu-lin after correction for hemoconcetration during
hemodialysis.

In conclusion, the present study showed that this cuprophane menbrane displays a bad profile of biocompatibility as well as a bad capacity to remove β₂­microglobulin when used in dialysis. Therefore other therapeutic alternatives have to be designed to prevent dialysis induced hypoxemia and β₂­microglobulin amyloidosis.
Alternative Title
The Effect of Cuprophane Hemodialysis on Complement Activation and β₂-Microglobulin Removal Rate
Keimyung Author(s)(Kor)
박근용
박성배
김현철
Publisher
School of Medicine
Citation
배장호 et al. (1994). Cuprophane 투석막이 혈장보체 활성화와 β₂-microglobulin제거율에 미치는 영향. 대한신장학회지, 13(3), 489–497.
Type
Article
ISSN
1225-0015
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37822
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.