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신이식후 발생한 용혈성 요독증후군 1예

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Author(s)
박성배김현철박관규권건영
Keimyung Author(s)
Park, Sung BaeKim, Hyun ChulPark, Kwan KyuKwon, Kun Young
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Journal Title
대한신장학회지
Issued Date
1991
Volume
10
Issue
1
Abstract
A hemolytic-uremic syndrome (HUS) in renal allograft recipients clinically is charaterized by microangiopathic hemolytic anemia, thrombocytopenia, hypertension and deterioration of graft function. De novo HUS usually occurs during cyclosporin-A (CyA) immunosuppression. The mechanisms that lead to CyA-associated HUS are not clear yet, but disturbance of prostacyclin synthesis in endothelial surface is suspected. We are reporting a case of CyA-associated HUS in a 30 year old female renal allograft recipient who received a kidney from her 52 year old mother. She developed hemolytic anemia, thrombocytopenia, hypertension and a gradual rise of serum creatinine level on the second day of transplantation. Initially she was given steroid pulse therapy under the assumption of acute rejection, without improvment. On the 12th day CyA treatment was discontinued and a percutaneous allograft biopsy was performed on the 17th day after transplantation. Histolgy of the graft showed numerous thrombi in the glomeruli capillary lumen and arterioles with fibrin deposits. Partial recovery of graft function occurred after cessation of CyA treatment.
Alternative Title
Cyclosporin-A Associated Hemolytic-Uremic Syndrome in Renal Allograft Recipient: A Case Report
Keimyung Author(s)(Kor)
박성배
김현철
박관규
권건영
Publisher
School of Medicine
Citation
박성배 et al. (1991). 신이식후 발생한 용혈성 요독증후군 1예. 대한신장학회지, 10(1), 118–125.
Type
Article
ISSN
1225-0015
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37868
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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