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암세포에서 NAG-1의 발현 및 기능

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Author(s)
임준희권택규
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Journal of Cancer Prevention
Issued Date
2008
Volume
13
Issue
1
Abstract
Nonsteroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) was identified from
indomethacin (a cyclooxygenase (COX) inhibitor)-induced gene library. NAG-1 is a member of TGF-β superfamily and is also known as macrophage inhibitory cytokine-1 (MIC-1), placental transforming growth factor β (PTGF-β), or prostate derived factor (PDF). Purified recombinant NAG-1 is able to inhibit lipopolysaccharide-induced TNF-α production in macrophages, suggesting that NAG-1 acts as an autocrine regulatory molecule. In vitro and in vivo NAG-1 has anti-tumorigenic and pro-apoptotic activities independent of COX inhibition. Not only NSAIDs but also several anti-tumorigenic compounds with chemopreventive activities, including resveratrol, genistein, catechins, and peroxisome proliferatorsactivated receptor-γ ligands, regulate NAG-1 expression in a prostaglandin-independent manner. Thus, pro-apoptotic activity of NAG-1 may provide a molecular basis to explain chemopreventive agentsmediated anti-tumorigenesis. However, the biological activity of NAG-1 is very poorly characterized, and reports in the literature show high expression in tumors. Thus, understanding the regulatory mechanism of NAG-1 by chemotherapeutic and chemopreventive agents and their implications in cancer treatments may provide a rational approach for using such as tumor therapeutic target. In this study, we summarize biological role of NAG-1 and discuss the potential molecular basis for their expressional regulation.
Alternative Title
Expression and Functional Role of NAG-1 in Cancer
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
임준희 and 권택규. (2008). 암세포에서 NAG-1의 발현 및 기능. Journal of Cancer Prevention, 13(1), 12~17-12~17.
Type
Article
ISSN
2288-3649
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38075
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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