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Cytogenetic Study in Suspicious Cases of Malignant Pleural Effusion

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Author(s)
Seung-Bum HanDae-Kwang Kim
Keimyung Author(s)
Han, Sung BeomKim, Dae Kwang
Department
Dept. of Internal Medicine (내과학)
Dept. of Medical Genetics (의학유전학)
Journal Title
Cancer Research and Treatment
Issued Date
2002
Volume
34
Issue
3
Abstract
Purpose: This study was performed to detect malignant cells in suspicious cases of malignant pleural effusion by cytogenetic analysis.
Materials and Methods: Eleven cases with pleural effusion were included in this study. Cells in pleural effusion were treated by direct, or short term, culture to prepare chromosomes. To analyze chromosomes, the G-banding method was used.
Results: Chromosome preparations succeeded in 10 cases. 5 cases had normal karyotypes, but in 2 of these cases malignant cells were detected on cytological examination. The other 5 cases had abnormal chromosomes, but on cytological examination showed normal cell appearances.
Conclusion: Cytogenetic analysis of pleural effusions is not used routinely, but is more sensitive than the cytological examination of malignant pleural effusions. So, chromosome analysis is a good diagnostic tool, when chromosomal abnormalities are detected in an effusion. If a combination of cytology and cytogenetic study are used, the chance of detecting malignant cells in pleural effusion will be higher, and then more invasive diagnostic procedures, such as thoracoscopy or thoracotomy, could be avoided.
Keimyung Author(s)(Kor)
한승범
김대광
Publisher
School of Medicine
Citation
Seung-Bum Han and Dae-Kwang Kim. (2002). Cytogenetic Study in Suspicious Cases of Malignant Pleural Effusion. Cancer Research and Treatment, 34(3), 234–238. doi: 10.4143/crt.2002.34.3.234
Type
Article
ISSN
1598-2998
DOI
10.4143/crt.2002.34.3.234
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38078
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
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