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위암 주변 점막의 장화생 유형 및 위암의 bcl-2, p53, c-erbB-2 단백질 발현

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Author(s)
조승제권건영
Keimyung Author(s)
Kwon, Kun Young
Department
Dept. of Pathology (병리학)
Journal Title
대한암학회지
Issued Date
1999
Volume
31
Issue
5
Abstract
Purpose: This study was carried out to clarify significance of types of intestinal metaplasia and roles of bcl-2, p53 and c-erbB-2 protein in the development of gastric carcinoma. Materials and Methods: Total one hundred fifty nine cases of surgically resected stomachs with benign ulcer (n=21), dysplasia (ns18) and gastric carcinoma (n=120) were studied histologically, histochemically and immunohistochemically. Results: Type III intestinal metaplasia was significantly more common in the carcinoma patients in older age group. Bcl-2 expression was found in 94.4% cases of dysplasia and 75.0% cases of carcinoma. Positivity for bcl-2 protein was significantly higher in intestinal type carcinomas than in diffuse type carcinomas (p=0.000). The expression of p53 protein showed 50.0% cases of dysplasia and 49,2% cases of carcinoma. The expression of p53 protein was significantly correlated with depth of invasion (p=0.000), regional lymph node metastasis (p=0.001)» and tumor size (p=0.001). C-erbB-2 protein was only expressed in 15.0% cases of carcinoma. The expression of c-erbB-2 protein was found more often in advanced carcinomas (p=0.001) and carcinomas with regional lymph node metastasis (p=0.003). Conclusion: Type III intestinal metaplasia was associated with age, but not with types of gastric carcinoma. Bcl-2 protein is probably involved in dysplastic lesion of gastric carcinogenic sequence and associated with intestinal type carcinoma, and p53 protein is also involved in dysplasia. p53 protein and c-erbB-2 protein may have a role of tumor invasion and nodal metastasis as poor prognostic factors.
Alternative Title
Type of Intestinal Metaplasia in the Surrounding Mucosa of Gastric Carcinoma and Expression of bcl-2, p53 and c-erbB-2 Protein in Gastric Carcinoma
Keimyung Author(s)(Kor)
권건영
Publisher
School of Medicine
Citation
조승제 and 권건영. (1999). 위암 주변 점막의 장화생 유형 및 위암의 bcl-2, p53, c-erbB-2 단백질 발현. 대한암학회지, 31(5), 898–911.
Type
Article
ISSN
0496-6872
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38097
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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