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위암의 조직형에 따른 HLA-DR 항원발현

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Author(s)
손수상김영헌김인호장은숙김상표
Keimyung Author(s)
Sohn, Soo SangKim, In HoChang, Eun SookKim, Sang Pyo
Department
Dept. of Surgery (외과학)
Dept. of Pathology (병리학)
Journal Title
대한암학회지
Issued Date
1993
Volume
25
Issue
6
Abstract
To prospect the significance of differences in HLA-DR antigen expression in two subtype of gastric carcinoma by Lauren's classification and its relationship with gastric inflammatory pattern, 60 cases of gastric carcinoma diagnosed from gastrectomy specimens were investigated. They were stained using the streptavidin biotin method with a mouse monoclonal antibody for class II HLA-DR antigen(Dako, Santa Fe, CA; HLA-DR/Alpha) at a concentration of 1 : 30.
The results were as follows:
Staining for HLA-DR antigen was diffuse or patchy or focal and was both membranous and cytoplasmic. Of the 60 cases of gastric carcinoma were evaluated, 46 were of intestinal type, 14 of the diffuse type. The overall incidence of HLA-DR antigen expression was 29/60(48.33%). Intestinal type gastric carcinoma was 27/46(58.69%), compared with 2/14(14.28%) in diffuse type. The rate of HLA-DR antigen expression in two types is significantly differentThe expression of HLA-DR antigen in incomplete intestinal metaplasia with inflammation might be affected by a microenviroment with lymphoid infiltrate in which contained T cells. Thus these results suggest that HLA-DR antigen expression in gastric carcinoma is related with chronic gastritis with incomplete intestinal metaplasia especially to intestinal type.
These suggest the notion that immunological mechanisms play a part in the initiation of gastric carcinoma, especially intestinal type, whereas diffuse type is thought to be related to genetic predisposition.
Alternative Title
Expression of HLA-DR Antigen in Different Histologic Types of Gastric Carcinoma
Keimyung Author(s)(Kor)
손수상
김인호
장은숙
김상표
Publisher
School of Medicine
Citation
손수상 et al. (1993). 위암의 조직형에 따른 HLA-DR 항원발현. 대한암학회지, 25(6), 818–825.
Type
Article
ISSN
0496-6872
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38100
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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