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유방암 제2병기 환자에서 림프절 미소전이가 예후에 미치는 영향 - 인슈린종 3예 보고 -

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Author(s)
강구정김형태정기용김유사이상한서인수
Keimyung Author(s)
Kang, Koo JeongKim, Hyoung TaeChung, Ki YongKim, You Sah
Department
Dept. of Surgery (외과학)
Journal Title
대한암학회지
Issued Date
1996
Volume
28
Issue
5
Abstract
This study was performed to identify the cancer cells in lymph nodes taken from women stage Ila breast cancer using routine hematoxyline-eosin (HE) stains.
Six hundred and thirty-four lymph nodes were taken from 42 cases of breast cancer. Among these, 31 cases were negative for lymph nodes metastasis and 11 were positive for lymph node metastasis. All 634 lymph nodes were immunostained.
Eight of 11 patients(72.7%) who had positive lymph nodes had at least one or more nodes stained by anti-epithelial membrane antibody and 7 of 11 patients(63.6%) who had positive nodes had at least one or more nodes stained by anti-cytokeratin (PAN-CK) antibody. Of the 31 cases of negative lymph nodes, 2 cases of occult micrometastases were detected by immunohistochemical stains. One of the 2 cases was stained by only one monoclonal antibody In the follow up study (a mean of 59.9 months), there were no important prognostic factors for 5 year survival rates according to the following 3 categories: age( <40 years vs. > =40 years), tumor size(<2.0 cm vs. > = 2.0 cm), and immunohistochemical stain. The presence of metastatic axillary lymph node was the most important prognostic factor for 5 year disease free survival (p=0.05). The immunohistochemical stain of the axillary lymph nodes was not significant for 5 year overall and disease free survival. One of the 2 patients who had negative axillary nodes by HE stain but positive nodes by immunohistochemical stains had a recurrence within 4 years and 11 months after mastectomy. Immunohistochemical stain for axillary lymph nodes of patients without lymph node metastases is a useful tool for detecting occult micrometastases, however, it is not helpful as a prognostic factor.
Alternative Title
Micrometastases of Axillary Lymph Nodes from Stage IIa Breast Cancer: Immunohistochemical Detection and Prognostic Significance
Keimyung Author(s)(Kor)
강구정
김형태
정기용
김유사
Publisher
School of Medicine
Citation
강구정 et al. (1996). 유방암 제2병기 환자에서 림프절 미소전이가 예후에 미치는 영향 - 인슈린종 3예 보고 -. 대한암학회지, 28(5), 819–828.
Type
Article
ISSN
0496-6872
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38102
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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