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면역억제제가 Lipopolysaccharide에 의한 생쥐의 간 및 뇌조직의 Nitric Oxide Synthase 활성도의 변화에 미치는 영향

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Author(s)
민병우한형수박정숙김중영
Keimyung Author(s)
Min, Byung Woo
Department
Dept. of Orthopedic Surgery (정형외과학)
Journal Title
대한약리학회지
Issued Date
1995
Volume
31
Issue
2
Abstract
To verify the effect of immunosuppressants on the endotoxin-induced increase in iNOS activity, the action of immunosuppressants, dexamethasone (1.5 mg/kg), azathioprine (5 mg/kg/day) and cyclosporine (10 mg/kg), were evaluated in mice pretreated with LPS.
The intraperitoneal injection of lipopolysaccharide (10 mg/kg) increased the nitric oxide synthase (NOS) activity in the brain and liver to maximum at 1 and 3 hours, respectively. The increase in NOS activity was blocked by the treatment with NOS inhibitor, LNAME(300 mg/kg) and aminoguanidine(100 mg/kg) ; a protein inhibitor, cycloheximide( 10 mg/kg); and a transcription inhibitor of inducible NOS (iNOS), dexamethasone(1.5 mg/kg).
Immunosuppressants, azathioprine (5 mg/kg) and cyclosporine (10 mg/kg), effectively blocked the increase in NOS activity.
These results suggest that iNOS expression plays an important role in LPS-induced the increase in NOS activity and that immunosuppressants can be used as candidate for therapeutic agents in endotoxemia.
Alternative Title
Effect of Immunolsuppressants on Lipopolysaccharide-Induced Changes of Nitric Oxide Synthase Activity in Liver and Brain of Mice
Keimyung Author(s)(Kor)
민병우
Publisher
School of Medicine
Citation
민병우 et al. (1995). 면역억제제가 Lipopolysaccharide에 의한 생쥐의 간 및 뇌조직의 Nitric Oxide Synthase 활성도의 변화에 미치는 영향. 대한약리학회지, 31(2), 233–239.
Type
Article
ISSN
0377-9459
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38113
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
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