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10개 이상 액와 림프절 전이를 보인 유방암 환자의 예후

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Affiliated Author(s)
강선희
Alternative Author(s)
Kang, Sun Hee
Journal Title
대한외과학회지
ISSN
1226-0053
Issued Date
2008
Abstract
Purpose: The most important prognostic factor in patients with operable breast cancer is lymph node involvement. The 6th edition of AJCC categorizes metastasis to more than 10 nodes as N3, or stage IIIc. Such patients have a high risk of recurrence and death. The purpose of this study was to evaluate the prognosis of these N3 patients.
Methods: Between 1991 and 2004, 141 patients with 10 or more positive lymph nodes were treated at our institution, and we retrospectively reviewed their medical records. We analyzed patient age, tumor size, number of metastatic lymph nodes, hormone receptor status, C-erb-B2 status, and treatment modality. Survival was calculated using the Kaplan-Meier method on SPSS 12.0 software.
Results: The median follow-up duration was 55.0 months (range 3∼182 months); 78 patients had recurrence, and 44 patients died. The 5-year disease-free survival and 5-year overall survival rates were 49.4% and 64.6%, respectively. The only prognostic factor for disease-free survival was tumor size. In patients with tumors less than 2 cm in size, the 5-year disease-free survival was 68.9%, while the 5-year disease-free survival was 27.7% in patients with tumors larger than 5 cm. Hormonal receptor status, C-erb-B2 status, number of metastatic lymph nodes, and treatment modality were statistically insignificant in predicting disease-free survival. None of these factors was significant for predicting overall survival, either.
Conclusion: The 5-year disease-free survival rate was 49.4%, and it was influenced only by tumor size. Adjuvant chemotherapy and adjuvant radiotherapy were not independent factors predicting survival. Early breast tumor detection is important in N3 breast cancer patients.
Alternative Title
Prognosis of Breast Cancer Patients with Ten or More Positive Lymph Nodes
Department
Dept. of Surgery (외과학)
Publisher
School of Medicine
Citation
김인환 and 강선희. (2008). 10개 이상 액와 림프절 전이를 보인 유방암 환자의 예후. 대한외과학회지, 75(4), 240–244.
Type
Article
ISSN
1226-0053
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38179
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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