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유방암 환자에서 혈청 내 HER-2/neu 세포외 도메인의 측정에 대한 고찰: 조직학적 방법 및 임상병리학적 요인과의 연관성

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Author(s)
강선희조지형하정숙권선영
Keimyung Author(s)
Kang, Sun HeeCho, Ji HyoungHa, Jung SookKwon, Sun Young
Department
Dept. of Surgery (외과학)
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Pathology (병리학)
Journal Title
대한외과학회지
Issued Date
2010
Volume
78
Issue
5
Abstract
Purpose: The extracelluar domain (ECD) of HER2 may be cleaved from the surface of cancer cells whereby serum HER2 ECD levels can be detected. We explored the correlation between serum HER2 ECD and tissue HER2 status and their relationship with clinicopathological parameters.
Methods: We included 125 patients with stage 0-3 breast cancer. The serum HER2 ECD level was measured by chemiluminescence immunoassay (ADVIA CentaurⓇ system). The tissue HER2 status was analyzed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) in all tumors. We reviewed the medical records retrospectively. The analyzed clinicopathological parameters were age, tumor size, histologic grade, vascular invasion, lymph node involvement, stage, estrogen receptor (ER) and CA 15-3.
Results: High serum HER2 ECD levels (≥15 ng/ml) were reported in 15 patients (12.0%). For tissue HER 2 status, 30 patients (24.0%) had positive results in FISH and 46 patients (37.0%) had strong positive results in IHC (3+). The specificity of serum HER2 ECD was 92.6% but the sensitivity was only 26.7%. The concordance between serum HER2 ECD and FISH tests was 23.3%. High serum HER2 ECD levels were significantly associated with old age (P=0.005), large tumor size (P=0.021), vascular invasion (P=0.001), lymph node involvement (P=0.010) and advanced stage (P<0.001). ER and CA 15-3 levels were not significantly related with serum HER2 ECD.
Conclusion: Serum HER2 ECD test could not be substituted for tissue HER2 status because of low concordance. However, high levels of serum HER2 were associated with large tumor size, lymph node involvement and advanced stage. We need to study serum HER2 ECD test as a role of prognostic marker.
Alternative Title
Evaluation of Serum HER-2/neu Extracelluar Domain in Breast Cancer Patients: Correlation with Tissue HER-2/neu Status and Clinicopathological Factors
Keimyung Author(s)(Kor)
강선희
조지형
하정숙
권선영
Publisher
School of Medicine
Citation
강선희 et al. (2010). 유방암 환자에서 혈청 내 HER-2/neu 세포외 도메인의 측정에 대한 고찰: 조직학적 방법 및 임상병리학적 요인과의 연관성. 대한외과학회지, 78(5), 271–276. doi: 10.4174/jkss.2010.78.5.271
Type
Article
ISSN
1226-0053
DOI
10.4174/jkss.2010.78.5.271
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38182
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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