유방 침윤성 소엽암의 임상적 특성

Abstract

A total of thirty-three patients with histologically confirmed infiltrating lobular carcinoma were found at the Department of Surgery, Keimyung University Dongsan Hospital, between September 1，1986 and August 31，1995. To identify the clinical characteristics of these patients, comparisons were made with patients with infiltrating ductal carcinoma and obtained the following results. 1) Of a total of 591 patients with breast cancer found during the same period, 33(5.6%) were infiltrating lobular carcinomas(ILC), and 425(71.9%) were infiltrating ductal carcino-mas(IDC). 2) The mean age of ILC and IDC were 47.3 and 47.0 years, respectively(p=0.90). 3) The average sizes of tumors of ILC and IDC were 3.9 cm and 4.0 cm, respectively(p= 0.77). 4) The degree of axillary lymph node metastasis was similar in both types of cancer(p= 0.33). 5) Modified radical mastectomy was the most commonly used method of surgical treatment followed by breast conservation procedures, and radical mastectomy. Breast conservation procedure was performed in only 2 patients with infiltrating lobular carcinoma. 6) The diagnostic accuracy of mammography was higher in ILC(93%) than in IDC(76%) patients (p=0.01). 7) The rates of ER & PR positivity in ILC were 78% and 82% respectively and these were 42% and 37%, respectively for IDC and the difference was statistically significant(ER： p<0.00, PR： p<0.00). Oncogene(Rb, P53, CerbB2, EGFR, PCNALI) expression showed no statistically significant differences in both types of cancer. 8) Five year survival rate in ILC was 92% and 5 year survival rate in IDC was 82%. There was no statistical difference between the two groups.