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췌장 내분비 종양의 임상양상 및 면역조직화학염색 특성

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Author(s)
이상목손창용강구정임태진조승제
Keimyung Author(s)
Kang, Koo JeongLim, Tae Jin
Department
Dept. of Surgery (외과학)
Journal Title
대한외과학회지
Issued Date
1999
Volume
56
Issue
1
Abstract
Background: Neuroendocrine tumors of the pancreas are classified according to the endocrine function as insulinomas gastrinomas somatostatinomas, or nonfunctioning tumors. However, the morphologic features are not different from each other. Therefore, we tried to compare correlations among the morphologic features, endocrine function, and the immunohistochemical reaction with specific monoclonal antibodies to the tumors.
Method: We reviewed the medical records of seven patients with pancreatic neuroendocrine tumors retrospectively, and analysed the clinical manifestations, the methods of diagnosis, the pathological characteristics and the results of surgery. Additionally, we compared the correlation between the clinical manifestations and the expression of immunohistochemical staining by using six different kinds of monoclonal antibodies to each tumor.
Results: The seven pancreatic neuroendocrine tumor patients were treated by surgical excision. Four patients had benign insulinomas, two had nonfunctioning malignant tumor and one patient had a benign nonfunctioning tumor associated with stomach cancer. The pattern of immunohistochemical stain of each tumor was not correlate with the clinical manifestations.
Conclusion: The morphologic study with H & E stain, even with immunohistochemical staining of pancreatic neuroendocrine tumor, cannot support differentiation of the functional diagnoses, such as insulinoma, gastrinoma, somatostatinoma, nonfunctional tumors and so forth.
Alternative Title
Clinical and Immunohistochemical Characteristics of Pancreatic Neuroendocrine Tumor -Immunohistochemical Analysis of 7 Tumors-
Keimyung Author(s)(Kor)
강구정
임태진
Publisher
School of Medicine
Citation
이상목 et al. (1999). 췌장 내분비 종양의 임상양상 및 면역조직화학염색 특성. 대한외과학회지, 56(1), 117–125.
Type
Article
ISSN
1226-0053
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38239
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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