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Catechol-O-Methyltransferase Activity from Regenerating Liver after Partial Hepatectomy in Rats

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Author(s)
You-Hee KimHye-Jung ChoiChun-Sik Kwak
Keimyung Author(s)
Kim, You HeeKwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
대한의생명과학회지
Issued Date
2005
Volume
11
Issue
1
Abstract
The change of catechol-O-methyltransferase (COMT) activity during regeneration of rat liver was studied. Cytosolic, mitochondrial and microsomal COMTs activities were estimated in regenerating rat livers over a period of ten days after 70% (median and left lateral lobes) partial hepatectomy. The values of Km and Vmax in the hepatic enzymes were also measured. The activities of cytosolic and microsomal COMTs in regenerating rat liver after partial hepatectomy were found to be significantly increased between the second and the third day. Whereas the mitochondrial COMT activity did not change. The Vmax values of the cytosolic and microsomal COMTs in the regenerating rat liver were significantly increased at the second day after partial hepatectomy, however, the Km values of the above hepatic enzymes did not vary in all the experimental groups. Therefore, the results suggest that the biosynthesis of COMT was increased during the regeneration of rat liver.
Keimyung Author(s)(Kor)
김여희
곽춘식
Publisher
School of Medicine
Citation
You-Hee Kim et al. (2005). Catechol-O-Methyltransferase Activity from Regenerating Liver after Partial Hepatectomy in Rats. 대한의생명과학회지, 11(1), 45–49.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38303
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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