계명대학교 의학도서관 Repository

Effects of Intravenous Administration of Taurocholate on Hepatic Aryl Sulfotransferase Activity in Cholestatic Rats

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Author(s)
Kyo-Cheol MunYou-Hee KimChun-Sik Kwak
Keimyung Author(s)
Mun, Kyo CheolKim, You HeeKwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
대한의생명과학회지
Issued Date
2005
Volume
11
Issue
1
Abstract
The possible mechanisms of increased aryl sulfotransferase (AST) isozymes activities in cholestatic rat liver were studied. Hepatic AST-I, II and -III, IV activities were determined from the experimental rats with common bile duct ligation (CBDL). The Michaelis-Menten constants in these hepatic enzymes were also measured. The activities of mitochondrial AST-I, II and -III, IV, and microsomal AST-III, IV as well as their Vmax values were found to be increased significantly in CBDL plus taurocholic acid (TCA) injected group than in the control group, such as CBDL alone groups. However, their Km values in the experimental groups did not vary. The results suggest that TCA stimulates biosynthesis of the AST in the liver.
Keimyung Author(s)(Kor)
문교철
김여희
곽춘식
Publisher
School of Medicine
Citation
Kyo-Cheol Mun et al. (2005). Effects of Intravenous Administration of Taurocholate on Hepatic Aryl Sulfotransferase Activity in Cholestatic Rats. 대한의생명과학회지, 11(1), 37–43.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38309
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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