계명대학교 의학도서관 Repository

Effects of Intravenous Administration of Taurocholic Acid on Liver Lysosomal α-D- and β-D-Mannosidase Activities in Rats with Extrahepatic Cholestasis

Metadata Downloads
Author(s)
So-Kyung ParkYou-Hee KimChun-Sik Kwak
Keimyung Author(s)
Kim, You HeeKwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
대한의생명과학회지
Issued Date
2004
Volume
10
Issue
2
Abstract
The effects of intravenously administered of high concentration of taurocholic acid (TCA) on α-D- and β-D-mannosidase activities in rat liver lysosomes were studied. These liver lysosomal enzymes, and serum lysosomal α-Dand β-D-mannosidase isozymes activities were determined in experimental rats with common bile duct ligation (CBDL). The liver lysosomal β-D-mannosidase activity as well as the serum lysosomal α-D- and β-D-mannosidase isozymes activities were found to be significantly increased in the CBDL plus TCA injected group than in the control group such as CBDL alone group. However, the liver lysosomal α-D-mannosidase activity was found to be significantly decreased in the CBDL plus TCA injected group. The above results suggest that TCA repress the biosynthesis of the lysosomal α-D-mannosidase and induce the biosynthesis of the lysosomal β-D-mannosidase in the liver. And that the elevated serum lysosomal α-D and β-D-mannosidase isozymes activities are most likely due to increased hepatocyte membrane permeability caused by TCA mediated liver cell necrosis.
Keimyung Author(s)(Kor)
김여희
곽춘식
Publisher
School of Medicine
Citation
So-Kyung Park et al. (2004). Effects of Intravenous Administration of Taurocholic Acid on Liver Lysosomal α-D- and β-D-Mannosidase Activities in Rats with Extrahepatic Cholestasis. 대한의생명과학회지, 10(2), 93–98.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38312
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.