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Effects of Intravenous Administration of Taurocholate on Hepatic Monoamine Oxidase A and B Activities in Cholestatic Rats

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Author(s)
Jun-Young DoChun-Sik Kwak
Keimyung Author(s)
Kwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
대한의생명과학회지
Issued Date
2004
Volume
10
Issue
4
Abstract
The possible mechanisms of decreased monoamine oxidase (MAO) A and B activities in cholestatic rat liver were studied. Hepatic and serum MAO activities were determined from the experimental rats with common bile duct ligation (CBDL). The Michaelis-Menten constants in these hepatic enzymes were also measured. The activities of mitochondrial MAO A and B, and mircosomal MAO B as well as their Vmax values were found to be decreased significantly in CBDL plus taurocholic acid (TCA) injected group than in the control group, such as CBDL alone groups. However, their Km values in the experimental groups did not vary. Serum MAO activity increased significantly in the CBDL plus TCA injected group than in the control group. The above results suggest that TCA represses biosynthesis of the MAO in the liver. The elevated activity of the serum MAO is believed to be caused by the increment of membrane permeability of hepatocytes upon TCA mediated liver cell necrosis.
Keimyung Author(s)(Kor)
곽춘식
Publisher
School of Medicine
Citation
Jun-Young Do and Chun-Sik Kwak. (2004). Effects of Intravenous Administration of Taurocholate on Hepatic Monoamine Oxidase A and B Activities in Cholestatic Rats. 대한의생명과학회지, 10(4), 421–427.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38313
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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