계명대학교 의학도서관 Repository

Effects of Intravenous Administration of Taurocholate on Serum Aryl Sulfotransferase Activity in Cholestatic Rats

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Author(s)
Kyo-Cheol MunYou-Hee KimChun-Sik Kwak
Keimyung Author(s)
Mun, Kyo CheolKim, You HeeKwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
대한의생명과학회지
Issued Date
2005
Volume
11
Issue
4
Abstract
Possible mechanisms of increased serum aryl sulfotransferase (AST) isozyme activities in cholestatic rats were studied. Serum AST-I, II and -III, IV isozymes activities were determined from the experimental rats with common bile duct ligation (CBDL) or choledocho-caval shunt (CCS). The activities of serum AST-I, II and -III, IV isozymes were found to be increased significantly in both the CCS plus taurocholic acid (TCA) injected group, and the CBDL plus TCA group than those in each control group, such as CCS or CBDL alone groups. The above results suggest that the elevated serum AST most likely due to increased hepatocyte membrane permeability caused by TCA mediated liver cell necrosis.
Keimyung Author(s)(Kor)
문교철
김여희
곽춘식
Publisher
School of Medicine
Citation
Kyo-Cheol Mun et al. (2005). Effects of Intravenous Administration of Taurocholate on Serum Aryl Sulfotransferase Activity in Cholestatic Rats. 대한의생명과학회지, 11(4), 503–508.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38318
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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