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Effects of Intravenous Administration of Taurocholic Acid on Hepatic Monoamine Oxidase A and B Activities in Rats with Choledocho-Caval Shunt

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Author(s)
Jun-Young DoKyo-Cheol MunYou-Hee KimChun-Sik Kwak
Keimyung Author(s)
Mun, Kyo CheolKim, You HeeKwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
대한의생명과학회지
Issued Date
2006
Volume
12
Issue
2
Abstract
The effects of intravenous administration of high concentration of taurocholic acid (TCA) on monoamine oxidase (MAO) A and B activities in rat liver mitochondria and microsomes were studied. These liver subcellular organelles and serum MAO activities were determined from the experimental rats with choledocho-caval shunt (CCS). The Michaelis-Menten constants in these hepatic enzymes were also measured. The activities of mitochondrial MAO A and B, and microsomal MAO B as well as their Vmax values were found to be decreased significantly in CCS plus TCA injected group then in the control group, such as CCS alone groups. However their Km values in the experimental groups did not vary. MAO of serum appeared in the CCS plus TCA injected groups only. The above results suggest that TCA represses biosynthesis of the MAO in the liver. The MAO of serum is believed to be caused by the increment of membrane permeability of hepatocytes upon TCA mediated liver cell necrosis.
Keimyung Author(s)(Kor)
문교철
김여희
곽춘식
Publisher
School of Medicine
Citation
Jun-Young Do et al. (2006). Effects of Intravenous Administration of Taurocholic Acid on Hepatic Monoamine Oxidase A and B Activities in Rats with Choledocho-Caval Shunt. 대한의생명과학회지, 12(2), 91–97.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38320
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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