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신이식 환자에서 만성거부반응의 위험인자

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Author(s)
김현철석 준박성배김형태조원현박철희박관규
Keimyung Author(s)
Kim, Hyun ChulPark, Sung BaeKim, Hyoung TaeCho, Won HyunPark, Choal HeePark, Kwan Kyu
Department
Dept. of Internal Medicine (내과학)
Dept. of Surgery (외과학)
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Journal Title
대한이식학회지
Issued Date
1997
Volume
11
Issue
1
Abstract
Chronic rejection is a major barrier to long-term renal allograft survival. Cyclosporine, though effective at reducing the graft loss due to acute rejection, has had little impact on the incidence of chronic rejection.
Between December 1984 and April 1995, 221 patients received a primary living donor kidney transplantation. In our study, 154 patients(70%) never had an episode of acute rejection, 22% had only one, and 8% had more the one. The incidence of chronic rejection was 12% in those who had no acute rejection, 39% in those with one or more rejection episode. The 5-year graft survival was 28% for recipients with biopsy-proven chronic rejection versus 83% for without(P <0.001). In an univariate analysis, donor age, serum creatinine level at 1 and 2 year post transplantation, cyclosporine dosage at year( < 4 mg/kg vs >= 4 mg/kg) were significant risk factors for chronic rejection. In a logistic regression of multivariate analysis, we found that risk factors for chronic rejection were acute rejection episode(P < 0.0001) and donor age(P<0.01).
Alternative Title
Risk Factors for Chronic Rejection in Renal Allograft Recipients
Keimyung Author(s)(Kor)
김현철
박성배
김형태
조원현
박철희
박관규
Publisher
School of Medicine
Citation
김현철 et al. (1997). 신이식 환자에서 만성거부반응의 위험인자. 대한이식학회지, 11(1), 49–53.
Type
Article
ISSN
1598-1711
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38396
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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