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성견의 연속 양측 폐이식 실험모델에서 24시간 폐보존 연구

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Author(s)
박창권권건영전석길김정식배제훈
Keimyung Author(s)
Park, Chang KwonKwon, Kun YoungZeon, Seok KilKim, Jung SikBae, Jae Hoon
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Dept. of Pathology (병리학)
Dept. of Nuclear Medicine (핵의학)
Dept. of Radiology (영상의학)
Dept. of Physiology (생리학)
Journal Title
대한이식학회지
Issued Date
1998
Volume
12
Issue
2
Abstract
Background: Numerous studies on safe, long term preservation for lung transplantation has been performed for the purpose of developing ideal preservation solution with extracellular type or intracellular type solutions and overcoming the shortage of donors. We prepared LPDG (low potassium dextran glucose)solution for lung preservation study. In this study we examined the efficacy of LPDG solution in 24-hour lung preservation by using of a sequential bilateral canine lung allotransplant model.
Method: Seven bilateral lung transplant procedures were performed using weight-matched pairs (23 to 26 Kg) of adult mongrel dogs. The donor lungs were flushed with LPDG solution and maintained hyperinflated with 100% oxygen at 10oC for a planned ischemic time of 24 hours for the lung implanted first. After sequential bilateral lung transplantation, dogs were maintained on a ventilator for 3 hours: arterial oxygen tension, pulmonary artery pressure, and pulmonary vascular resistance were determined in the recipients hourly after bilateral reperfusion and compared with pretransplant-recipient values, which used as controls. After 2 hours of reperfusion, the chest X-ray, computed tomogram and lung perfusion scan were performed for assessment of early graft lung function. And pathological examinations for ultrastructural findings of alveolar structure and endothelial structure of pulmonary artery were performed.
Results: Five dogs of seven experiments had successfully finished the whole assessments after bilateral reperfusion for three hours. Arterial oxygen tension in the recipients was markedly decreased in immediate reperfusion period but gradually recovered after reperfusion for three hours. The pulmonary artery and pulmonary vascular resistance showed singificant elevation (p<0.05 versus control values) but also recovered after reperfusion for three hours (p<0.05 versus immediate period value). The ultrastructural findings of alveolar structure and endothelial structure of pulmonary artery showed reversible mild injury in 24 hours of lung preservation and reperfusion.
Conclusions: The present study suggests that LPDG solution provide excellent preservation and
transplanted lung function after 24 hours of preservation in a canine model in which the dog is completely dependent on the fuction of transplanted lung.
Alternative Title
24-hour Lung Preservation Study in a Canine Sequential Bilateral Lung Tranplant Model
Keimyung Author(s)(Kor)
박창권
권건영
전석길
김정식
배재훈
Publisher
School of Medicine
Citation
박창권 et al. (1998). 성견의 연속 양측 폐이식 실험모델에서 24시간 폐보존 연구. 대한이식학회지, 12(2), 161–171.
Type
Article
ISSN
1598-1711
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38411
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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