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신장이식 500예의 임상적 고찰

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Author(s)
김주성김형태조원현박성배김현철박철희주신헌
Keimyung Author(s)
Kim, Hyoung TaeCho, Won HyunPark, Sung BaeKim, Hyun ChulPark, Choal Hee
Department
Dept. of Surgery (외과학)
Dept. of Internal Medicine (내과학)
Dept. of Urology (비뇨의학)
Journal Title
대한이식학회지
Issued Date
2001
Volume
15
Issue
1
Abstract
Purpose: Five hundreds of renal transplantation were performed in the our institute from November, 1982 to April, 2000. During this period, there were two big changes of immunosuppressive regimen. These are introduction of cyclosporin microemulsion formula (Neoral®) in April, 1994 and mycophenolate mofetil (MMF) in April, 1997. So, the result of our 500 consecutive renal transplantation was analysed and compared according to the regimen. Methods: We analysed the result of our 500 renal transplantation by retrospective chart review. And we compared the result according to the regimen. Results: Mean age of recipients were 33.6 years and male to female ratio was 2.14 : 1. There was 18 retransplantation and 18 pediatric transplantation. Overall 1 year, 3 year and 5 year graft survial was 95,38%, 81.65% and 70.56%. And the patient survival was 96.78%, 92.31% and 89.46%, respectively. Before the introduction of Neoral (n=285), acute rejection during first 6 months (AR6mo) was 0.52 ± 1.09 and serum creatinine level at 12 months post-tranplant (Cr12mo) was 1.954± 1.488 and 1 year (1YSR), 3 year (3YSR) and 5 year (5YSR) graft survival was 93.64%, 77.66% and 65.32%. After introduction of Neoraland before MMF (n=134), AR6mo and Cr12mo was 0.62±1.83 and 1.625±1.203 and 1YSR, 3YSR and 5YSR was 96.27%, 87.03% and 79.97%, respectively. After addition of MMF (n=74), AR6mo and Cr12mo was 0.19±0.39 and 1.434± 0.773 and 1YSR and 3 YSR was 95.93% and 95.93%. Because of short term follow up for the last group, long term survival rate was indefinable. Conclusion: With advancement of immunosuppressive agents and accumulation of clinical experiences, short term result of the kidney transplantation was improved. Further evaluation of long term result is needed.
Alternative Title
Single Center Experience of 500 Consecutive Renal Transplantation
Keimyung Author(s)(Kor)
김형태
조원현
박성배
김현철
박철희
Publisher
School of Medicine
Citation
김주성 et al. (2001). 신장이식 500예의 임상적 고찰. 대한이식학회지, 15(1), 8–12.
Type
Article
ISSN
1598-1711
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38425
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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