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베타3-아드레날린성 수용체 유전자 변이와 체지방 분포

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Author(s)
윤태승김용득김혜순김미정서영성권중혁최진수김정국하승우김보완원규장이형우손호상이지현윤현대김원호윤영길이인규
Keimyung Author(s)
Kim, Hye SoonLee, In KyuSuh, Young SungKwon, Jung HyeokChoi, Jin Soo
Department
Dept. of Internal Medicine (내과학)
Dept. of Family Medicine (가정의학)
Dept. of Radiology (영상의학)
Journal Title
대한내분비학회지
Issued Date
2003
Volume
18
Issue
2
Abstract
Background: Reasons for obesity include environmental factors and, more largely so, genetic factors. There have been many studies on these genetic factors. So far, genes related to obesity such as Leptin, Uncoupling Protein (UCP), Peroxisome proliferator activated receptor-gamma(PPAR-γ), and Beta3-adrener-gic receptor(ß3-AR) gene have been discovered. Among these, ß3-AR is expressed in visceral adipose tissue and is thought to contribute to the regulation of resting metabolic rate and lipolysis. The missense mutation of ß3-AR gene, resulting in replacement of tryptophan by arginine at position 64(Trp64Arg), is associated with decreased resting metabolic rate and weight gain. WE performed this study to determine if Trp64Arg polymorphism of ß3-AR gene is associated with obesity in Koreans. Method: We investigated the relationship between the ß3-AR gene mutation and body mass index (BMI), waist circumference, hip circumference, waist to hip ratio (VSR), and lipid profile. 198 subjects were included in this study of which 97 were of normal weight and 101 were obese. Anthropometric data was obtained from physical examination and medical records. Result: In the cases of ß3-AR gene mutation of the obese group, the ratio of Trp/Arg and Arg/Arg are 43% and 5%, respectively, which were higher than the normal group (36%, 1%), although a statistical significant was not found. There was significant difference in the are of subcutaneous fat. Normal group (Trp/Trp) measured at 213.9±109.6cm² versus 244.0±127.7cm² (Trp/Arg) and 323.9±189.9cm²(Arg/Arg) for the mutation groups. Circumference of waist, circumference of hip, WHR, area of visceral fat, and VSR were higher in the mutation groups than in normal subject, but not significantly different. Conclusion: These results suggest that a genetic mutation in the ß3-AR gene can affect body fat composition, and is associated with obesity in Korean adults (J Kor Soc endocrinol 18:184~192,2003). Key Words: Obesity, Beta3-adrenergic receptor, Subcutaneous fat
Alternative Title
Association of Polymorphism in ß3-Adrenergic Receptor Gene with Fat Distribution
Keimyung Author(s)(Kor)
김혜순
이인규
서영성
권중혁
최진수
Publisher
School of Medicine
Citation
윤태승 et al. (2003). 베타3-아드레날린성 수용체 유전자 변이와 체지방 분포. 대한내분비학회지, 18(2), 184–192.
Type
Article
ISSN
2093-596X
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38449
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Family Medicine (가정의학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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