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관상동맥우회술 시 동맥도관 경련의 예방 효과 : 술 중 Nitroglycerin 및 Diltiazem의 비교

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Author(s)
이용철장영호유진균김진모박남희최세영
Keimyung Author(s)
Lee, Yong CheolJang, Young HoKim, Jin MoPark, Nam HeeChoi, Sae Young
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
Korean Journal of Anesthesiology
Issued Date
2005
Volume
48
Issue
3
Abstract
Background: Use of radial artery (RA) for coronary artery bypass grafting (CABG) is an increasingly common practice.
The objective of our study was to compare the effects of two drugs as antispastic agents in patients undergoing CABG.
Methods: Sixty patients, submitting to CABG using the RA, were randomly assigned to two treatment groups (n = 30 in
each group). Following the induction of anesthesia, the two groups were administered either 0.2-2μg/kg/min nitroglycerin or
0.05-0.1 mg/kg/hr diltiazem as a continuous IV infusion. CABG in both groups was performed as per standard surgical protocol.
Results: The peak serum creatinine phosphokinase-MB level (59.3 ng/ml for nitroglycerin treatment versus 57.7 ng/ml for
diltiazem treatment), postoperative ejection fraction (52.3% versus 48.4%), duration of stay in the ICU and total length of hospital
stay were not significantly different between the groups (P > 0.05). However, the need for inotropic agents to prevent or treat
intraoperative hypotension was less for patients in the nitroglycerin group than for patients in the diltiazem group (60.0% to 83.3%).
Conclusions: Our results indicate that nitroglycerin is superior to diltiazem as an antispastic agent. We suggest that nitroglycerin
should be the agent for choice for the prevention of conduit RA spasm. (Korean J Anesthesiol 2005; 48: 274∼81)
Alternative Title
Preventive Effect of Conduit Vessel Spasm after Coronary Artery Bypass Grafting Surgery
Keimyung Author(s)(Kor)
이용철
장영호
김진모
박남희
최세영
Publisher
School of Medicine
Citation
이용철 et al. (2005). 관상동맥우회술 시 동맥도관 경련의 예방 효과 : 술 중 Nitroglycerin 및 Diltiazem의 비교. Korean Journal of Anesthesiology, 48(3), 274–281.
Type
Article
ISSN
2005-6419
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38533
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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