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과민성방광 환자에서 Propiverine Hydrochloride 40mg의 효과 및 안전성: 전향적, 다기관, 관찰 연구

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Author(s)
김수진조원열허정식서주태양상국이규성이주환주명수김하영박철희김준철
Keimyung Author(s)
Park, Choal Hee
Department
Dept. of Urology (비뇨의학)
Journal Title
대한배뇨장애요실금학회지
Issued Date
2008
Volume
12
Issue
2
Abstract
Purpose : This study aims to compare the efficacy and safety of propiverine hydrochloride (propiverine) 40mg for the treatment of overactive bladder (OAB).
Material and Methods : Total of 284 patients (male:86, female:198) with OAB were included in this study. The patients were treated with propiverine 20mg twice daily or 40mg once daily for 8 weeks. The initial evaluation included with history taking, physical examination, International Prostatic Symptom Score (IPSS), IPSS QoL and consecutive voiding diaries for 3 days. After a 8-week treatment, IPSS, IPSS QoL, patients perception of treatment benefit, global assessment of efficacy by physicain and safety were evaluated.
Results : Two hundred eighteen patients were treated with propiverine 20mg twice daily and 66 patients treated with 40mg once daily. The 59 patients had been treated previously with anticholinergics. After a 8-week treatment, IPSS score (total, voiding and storage subscore) and IPSS QoL were improved in all patients (p<0.05). After a 8-week with propiverine 40mg once daily, improvement of IPSS score was noted in the patients non-responsive to anticholinergics previously (p<0.05). The patients treated with propiverine 40mg once daily showed much more symptomatic improvements assessed by physicians than 20mg twice daily (p<0.05). The overall side effect was noted in the 13.4% patients and the most common side effect was dry mouth.
Conclusion : Propiverine 40mg once daily is considered to reduce the symptom of OAB effectively and can be used safely in the patients with OAB. Treatment with propiverine 40mg is seemed to show more improvement in the unsatisfactory patients with previous anticholinergics. (J Korean Continence Soc 2008;12:114-20)
Key Words: Overactive bladder, Propiverine hydrochloride, Treatment outcome
Alternative Title
Efficacy and Safety of Propiverine Hydrochloride 40mg in Treatment of Overactive
Bladder : Prospective, Multicenter, Observational study
Keimyung Author(s)(Kor)
박철희
Publisher
School of Medicine
Citation
김수진 et al. (2008). 과민성방광 환자에서 Propiverine Hydrochloride 40mg의 효과 및 안전성: 전향적, 다기관, 관찰 연구. 대한배뇨장애요실금학회지, 12(2), 114–120. doi: 10.5213/jkcs.2008.12.2.114
Type
Article
ISSN
1598-186X
DOI
10.5213/jkcs.2008.12.2.114
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38595
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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