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간접 흡연에 의한 폐조직의 형태학적 변화

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Author(s)
권건영전지민김상표박관규김대현
Keimyung Author(s)
Kwon, Kun YoungKim, Sang PyoPark, Kwan KyuKim, Dae Hyun
Department
Dept. of Pathology (병리학)
Dept. of Family Medicine (가정의학)
Journal Title
대한병리학회지
Issued Date
1999
Volume
33
Issue
6
Abstract
Chronic bronchiolitis is a condition associated with cigarette smoking, and later associated with pulmonary parenchymal alteration and progressive deterioration of lung function. Early respiratory bronchiolitis was produced in Sprague-Dawley rats by indirect inhalation of cigarette smoke daily in a smoke exposure chamber designed by authors for 1 month. Experimental group A (n=5) was sacrificed after having smoked 30 cigarettes, group B (n=5) after 80 cigarette, and group C (n=7) after 140 cigarettes, respectively. Examination of morphologic changes in the lungs was done on light microscope, transmission and scanning electron microscopes. Light microscopically, increase in number of goblet cells in the bronchial mucosa, brown-pigmented macrophages in the alveoli, multifocal alveolar collapse adjacent to the bronchioles, dilatation of alveolar ducts and alveolar spaces were observed. Transmission electron microscopically, irregularly shaped Clara cells, alveolar wall collapse, and focally type I epithelial cell injury were seen. Scanning electron microscopically, scattered alveolar collapse, irregular dilatation of alveolar ducts, alveolar spaces and interalveolar pores (pores of Kohn) were seen. The terminal and respiratory bronchioles showed morphological alteration of Clara cells, but no evidence of cellular bronchiolitis or bronchiolar obstruction. We conclude that sidestream smoke induces an early respiratory bronchiolitis including aggregates of brown pigmented macrophages and varying degrees of structural alteration of adjacent pulmonary parenchyma.
Key Words: Sidestream smoke; Respiratory bronchiolitis; Transmission and scanning electron microscopy
Alternative Title
Morphologic Changes of Pulmonary Tissue Secondary to Sidestream Cigarette Smoke.
Keimyung Author(s)(Kor)
권건영
김상표
박관규
김대현
Publisher
School of Medicine
Citation
권건영 et al. (1999). 간접 흡연에 의한 폐조직의 형태학적 변화. 대한병리학회지, 33(6), 395–403.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38604
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Family Medicine (가정의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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