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난소의 장액성 종양에서의 p27kip1과 Cyclin D1 발현에 대한 조사

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Author(s)
권선영장은숙권건영박관규김수경
Keimyung Author(s)
Kwon, Sun YoungChang, Eun SookKwon, Kun YoungPark, Kwan KyuKim, Soo Kyung
Department
Dept. of Pathology (병리학)
Dept. of Pharmacology (약리학)
Institute for Medical Science (의과학연구소)
Journal Title
대한병리학회지
Issued Date
2001
Volume
35
Issue
3
Abstract
Background : p27kip1 is a member of the Cip/Kip family of the cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene. Decreased expression of p27kip1 is associated with high histologic grade and poor prognosis in a variety of human tumors.
Methods : Sixty-six cases of serous epithelial ovarian tumors were investigated by immunohistochemical staining for p27kip1, cyclin D1, and Ki-67. Clinicopathologic parameters (WHO classification, histologic grade and FIGO stage) were compared with the incidence of p27kip1, cyclin D1 and Ki-67 protein expression in ovarian serous tumors. Results : Reduced expression of p27kip1 was found more freguently in serous cystadenocarcinoma than in serous cystadenoma and borderline malignancy (p<0.05). The decreased expression of p27kip1 was correlated with a high histologic grade and an advanced FIGO stage. Overexpression of cyclin D1 is associated with borderline malignancy and grade I serous cystadenocarcinoma. An inverse relationship was observed between the p27kip1 protein and the Ki-67 labeling index within serous cystadenocarcinoma, but it was not significant. Conclusions : Reduced expression of p27kip1 protein plays an important role in the biologically aggressive behavior of serous epithelial ovarian tumors and might represent a useful prognostic marker for predicting the recurrence in primary ovarian tumors.
Key Words : p27, Cyclin D1, Ovarian neoplasms, Epithelial
Alternative Title
Expression of p27kip1 and Cyclin D1 in Serous Epithelial Ovarian Tumors
Keimyung Author(s)(Kor)
권선영
장은숙
권건영
박관규
김수경
Publisher
School of Medicine
Citation
권선영 et al. (2001). 난소의 장액성 종양에서의 p27kip1과 Cyclin D1 발현에 대한 조사. 대한병리학회지, 35(3), 220–225.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38607
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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