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난소종양에서의 Melanoma Antigen Genes (MAGE)와 Synovial Sarcoma on X chromosome (SSX)의 발현

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Author(s)
김영옥박진경김광휘박종욱전창호김원장희경
Keimyung Author(s)
Park, Jong Wook
Department
Dept. of Immunology (면역학)
Journal Title
대한병리학회지
Issued Date
2004
Volume
38
Issue
6
Abstract
Background : Several cancer-testis antigen genes or gene families have been isolated to date, including Melanoma Antigen Gene (MAGE) and Synovial Sarcoma on X chromosome (SSX). This study attempted to investigate the possibility of immunotherapy for ovarian cancer and to explore the prevalence of the expression of MAGE and SSX.
Methods : The fresh tissue samples were obtained from 5 cases of normal ovaries, 6 cases of non-neoplastic disease, 21 cases of benign ovarian tumors, and 12 cases of malignant ovarian tumors. The expression of MAGE A1-6 and SSX 1-9 was detected by nested reverse transcriptionpolymerase chain reaction using each common primers sets for MAGE A1-6 and SSX 1-9.
Results : The expression rate of MAGE 1-6 mRNA was 23.0% (5/21) for the benign ovarian tumors and 91.7% (11/12) for the malignant ovarian tumor, whereas the normal ovaries (0/5) and non-neoplastic ovarian tissues (0/6) did not express MAGE (p<0.05). The expression rate of SSX was 40.0% (2/5) for the normal ovaries, 23.0% (5/21) for the benign ovarian tumors, and 33.3% (4/12) for the malignant ovarian tumors, while the non-neoplastic ovarian tissues showed no expression of SSX (p>0.05). A relationship between the two genes was not observed (kappa coefficient=0.32). Conclusions : These results suggest that the gene products of MAGE and SSX can be useful for the immunotherapy of ovarian cancer patients and that MAGE can be a more promising target than SSX from the viewpoint of applicability
and cancer-specificity.
Key Words : Ovarian cancer; MAGE; SSX; Common primers
Alternative Title
Expression of Melanoma Antigen Gene (MAGE) and Synovial Sarcoma on X chromosome (SSX) in Ovarian Tumors
Keimyung Author(s)(Kor)
박종욱
Publisher
School of Medicine
Citation
김영옥 et al. (2004). 난소종양에서의 Melanoma Antigen Genes (MAGE)와 Synovial Sarcoma on X chromosome (SSX)의 발현. 대한병리학회지, 38(6), 372–377.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38609
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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