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방사선조사로 유발된 실험적 신 손상에서의 Captopril의 효과

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Author(s)
배지연장은숙김옥배
Keimyung Author(s)
Chang, Eun SookKim, Ok Bae
Department
Dept. of Pathology (병리학)
Dept. of Radiation Oncology (방사선종양학)
Institute for Medical Science (의과학연구소)
Journal Title
대한병리학회지
Issued Date
2000
Volume
34
Issue
3
Abstract
The angiotensin I converting enzyme inhibitor (Captopril) has recently been studied extensively in various experimental models of radiation injury and has proven its protective effects in various organs, such as the lungs, gastrointestinal tract, and kidneys. Twenty-three Sprague-Dawley rats were divided into experimental and control group. The experimental group was divided into two large groups: the first one received a single dose of 18 Gy irradiation from an electron beam on the local field of the kidney region only, and the second group received captopril per oral continuously after the same doses of irradiation. The second experimental group was divided into four subgroups by captopril doses: 62.5 mg/l, 125 mg/l, 250 mg/l, and 500 mg/l, respectively. On light and electron microscopy, the kidneys of the irradiated rats with no captopril treatment showed diffuse glomerular contraction, congestion with occlusion and focal necrosis of the endothelial, and mesangial cells. The tubules showed ballooning degeneration, desquamation, and diffuse coagulation necrosis. Captopril treated rats, especially those given a high dose (more than 250 gm/l), revealed a marked reduction of the tubular and glomerular injuries. There was a statistically significant difference in the degree of renal injury among the experimental groups (p<0.05). The result of this study suggests that an administration of high dose captopril might prevent radiation-induced renal injury, especially in the early post-irradiation period.
Key Words: Radiation; Renal injury; Captopril
Alternative Title
Protective Effects of Captopril in Radiation-Induced Renal Injury in Rats.
Keimyung Author(s)(Kor)
장은숙
김옥배
Publisher
School of Medicine
Citation
배지연 et al. (2000). 방사선조사로 유발된 실험적 신 손상에서의 Captopril의 효과. 대한병리학회지, 34(3), 214–224.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38617
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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