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염화 카드뮴 간 손상에 관한 광학 및 전자현미경적 연구

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Author(s)
박관규김영호장은숙장무응권건영
Keimyung Author(s)
Park, Kwan KyuKwon, Kun YoungChang, Eun Sook
Department
Dept. of Pathology (병리학)
Journal Title
대한병리학회지
Issued Date
1992
Volume
26
Issue
1
Abstract
This study was carried out to investigate the light and electron microscopic findings of the livers of rats after an intraperitoneal injection of cadmium chloride. The Sprague-Dawley rats were intraperitoneally injected with cadmium chloride dissolved in water, once a day for three days. These animals were sacrificed at 1, 3, 8, and 24 hr after the last injection. Control groups of the rats were also sacrificed in the same manner. The liver was extirpated and examined by both light and electron microscopy. The results obtained are as follows: The parenchyma of the liver shows focal neutrophilic infiltration and spotty necrosis. The hepatocytes show fatty change, ballooning degeneration, swelling of the endoplasmic reticulum and mitochondria, increase numbers of secondary lysosomes and residual bodies. Focal patic venules and sinusoids of the liver are congested. The Kupffer cells are increase in number. Therefore, it can be concluded that the cadmium is directly acted to hepatocytes resulting in cellular injuries and deposits in the fat droplets of the cytoplasm of the hepatocytes, not Ito cells as previously suggeted.
Key Words: Cadmium; Liver; Electron microscopy; Rat
Alternative Title
Light and Electron Microscopic Study in Rat Livers Following Cadmium Chloride Administration.
Keimyung Author(s)(Kor)
박관규
권건영
장은숙
Publisher
School of Medicine
Citation
박관규 et al. (1992). 염화 카드뮴 간 손상에 관한 광학 및 전자현미경적 연구. 대한병리학회지, 26(1), 28~39-28~39.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38623
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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