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위선암조직에서 HLA-DR 및 Secretory Component 발현에 관한 면역조직화학적 분석

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Author(s)
배지연손수상장은숙
Keimyung Author(s)
Chang, Eun SookSohn, Soo Sang
Department
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Journal Title
대한병리학회지
Issued Date
1996
Volume
30
Issue
4
Abstract
Sixty one cases of gastric adenocarcinoma were studied immunohistochemically for expression of HLA-DR and secretory component(SC) in order to analyze the relationship between expression of these in gastric cancer cells and the adjacent mucosa. Immunostaining was detected within the cytoplasm and on the cell memgrane. The rate of HLA-DR and SC expressions in cancer cells were 59.0% and 49.2%, respectively, and 52.5%/52.5% and 31.2%/50.8% the mucosa in adjacent/remote from the site of to cancer. The SC expression in the adjacent mucosa was lower than that of the remote mucosa(p=0.027). The HLA-DR expression in the cancer cells in the intestinal type of gastric adenocarcinoma(73.9%) was higher than that of the diffuse type(14.3%) and it was statistically significant(p=0.02). The presence of an increased amount of lymphoid infiltration in the gastric mucosa was closely related to the expression of HLA-DR and SC. Decreased or absent expression of SC at the transitional mucosal cells was possibly a result of exposure to genotoxic agents due to the lack of protective function of SC-IgA. From these results, one can postulate that the expression of HLA-DR and SC may play an important role in atleration in microenvironment with lymphoid infiltration.
Key Words: Gastric adenocarcinoma; HLA-DR antigen; Secretory component; Immunostaining; Adjacent/ remote mucosa
Alternative Title
Immunohistochemical Analysis of HLA-DR and Secretory Component Expression in Gastric Adenocarcinoma.
Keimyung Author(s)(Kor)
장은숙
손수상
Publisher
School of Medicine
Citation
배지연 et al. (1996). 위선암조직에서 HLA-DR 및 Secretory Component 발현에 관한 면역조직화학적 분석. 대한병리학회지, 30(4), 293–300.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38624
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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