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위의 원발성 림프종에서 bcl-2 및 p53 단백의 발현

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Author(s)
조영록강유나이상숙송홍석손수상김동석
Keimyung Author(s)
Kang, Yu NaLee, Sang SookSong, Hong SukSohn, Soo Sang
Department
Dept. of Pathology (병리학)
Dept. of Internal Medicine (내과학)
Dept. of Surgery (외과학)
Journal Title
대한병리학회지
Issued Date
1998
Volume
32
Issue
11
Abstract
The bcl-2 gene is a proto-oncogene which extends cell survival by blocking apoptosis. Bcl-2 expression has been detected in many types of nodal and MALT lymphoma. The p53 gene is a tumor suppressor gene and p53 mutation is the most common genetic alteration in human malignancies. The relationship between the expression of bcl-2 and p53 protein in primary gastric lymphoma has been rarely reported. The authors investigated the expression of bcl-2 and p53 protein in 37 cases of primary gastric lymphoma by immunohistochemical method using bcl-2 and p53 monoclonal antibodies. There were five cases of low grade B-cell MALT lymphomas and thirty two cases of high grade B-cell lymphomas. Fifteen of 37 cases (41%) showed bcl-2 protein expression in the cytoplasm of tumor cells and 26 cases (70%) showed p53 protein expression in the nucleus of tumor cells. Bcl-2 protein was detected in 4 of 5 (80%) low grade MALT lymphomas, and in 11 of 32 (34%) high grade lymphomas. There was no significant correlation between bcl-2 expression and histologic grade of primary gastric lymphomas (p>0.05). p53 protein was positive in 25 of 32 (78%) high grade lymphomas, and in 1 of 5 (20%) low grade MALT lymphomas. The expression of p53 protein is significantly higher in high grade lymphoma than in low grade MALT lymphoma (p<0.05). The p53 expression in the bcl-2 negative cases (86%) was significantly higher than in the bcl-2 positive cases (47%). There was an inverse relationship between bcl-2 and p53 expression in primary gastric lymphoma. These results suggest that bcl-2 and p53 expression in primary gastric lymphoma may be involved in the transition from low grade MALT lymphoma to high grade lymphoma.
Key Words: bcl-2; p53; Gastric lymphoma; Mucosa-associated lymphoid tissue
Alternative Title
Expression of bcl-2 and p53 Protein in Primary Gastric Lymphomas.
Keimyung Author(s)(Kor)
강유나
이상숙
송홍석
손수상
Publisher
School of Medicine
Citation
조영록 et al. (1998). 위의 원발성 림프종에서 bcl-2 및 p53 단백의 발현. 대한병리학회지, 32(11), 978–984.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38625
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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