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일차성 아교모세포종에서 염색체 9p21-22 부위 유전자의 이상

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Author(s)
도홍직서성일김동원김일만임만빈손은익권건영이상숙김상표
Keimyung Author(s)
Kim, Dong WonKim, ElYim, Man BinSon, Eun IkSuh, Seong IlKwon, Kun YoungLee, Sang SookKim, Sang Pyo
Department
Dept. of Neurosurgery (신경외과학)
Dept. of Microbiology (미생물학)
Dept. of Pathology (병리학)
Journal Title
대한병리학회지
Issued Date
2002
Volume
36
Issue
6
Abstract
Background : Glioblastomas are one of the most common and aggressive malignant glial tumors occuring in the central nervous system. This study analyzed the status of p15INK4b, p14ARF, p16INK4a, MTAP, IFNA, and IFNB genes in 36 primary glioblastomas to investigate whether the inactivation of these genes participate in primary glioblastoma tumorigenesis.
Methods : We used polymerase chain reaction, polymerase chain reaction/single strand conformational polymorphism (PCR/SSCP) analysis, and methylation-specific PCR. Results : Homozygous deletions at the p16INK4a gene were detected in 11 cases (30.5%) of 36 primary glioblastomas, and the promoter hypermethylation was found in 3 cases (8.3%) of 36 primary glioblastomas. In mutational analysis for the p16INK4a gene by PCR/SSCP, there was no abnormal mobility-shifted band in 36 cases of primary glioblastomas. The overall frequency of p16INK4a alterations including homozygous deletion and promoter hypermethylation in 36 primary glioblastomas was 38.8% (14 of 36). Deletions of p15INK4b were noted in 4 cases (11.1%), whereas deletions of the p14ARF and MTAP genes were detected in 1 case of 36 cases of primary glioblastomas. But deletions of the INFA and B genes were not found. Conclusions : These results suggest that alterations of the p16INK4a gene can be important mechanisms of the tumorigenesis of primary glioblastomas, and the p16INK4a gene is inactivated by mechanisms including homozygous deletion and promoter hypermethylation.
Key Words : Brain Neoplasms-Glioblastoma-Chromosomes, Human, Pair 9-Genes, p16
Alternative Title
Alterations of 9p21-22 Region Encoding Genes in Primary Glioblastomas
Keimyung Author(s)(Kor)
김동원
김엘
임만빈
손은익
서성일
권건영
이상숙
김상표
Publisher
School of Medicine
Citation
도홍직 et al. (2002). 일차성 아교모세포종에서 염색체 9p21-22 부위 유전자의 이상. 대한병리학회지, 36(6), 394–399.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38627
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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