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자궁경부암종에서 암 전이의 조기 발견을 위한 면역조직화학 연구

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Author(s)
박관규권선영제갈문영한상미장은숙차순도한인숙
Keimyung Author(s)
Park, Kwan KyuKwon, Sun YoungChang, Eun SookCha, Soon Do
Department
Dept. of Pathology (병리학)
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
대한병리학회지
Issued Date
2001
Volume
35
Issue
5
Abstract
Background : Adhesion molecules are important in the maintenance of normal epithelial structure, and altered expression of these molecules may be important in epithelial tumors, particularly in the processes of invasion and metastasis. Methods : We have examined the expression of E-cadherin, cathepsin-D, CD44, CD44v6, nm23 and transforming growth factor- 1 (TGF- 1) proteins in the cervical squamous cell carcinoma to evaluate the prognostic significance of these molecules.
Results : Immunostain for E-cadherin was highly expressed in the majority of cases of cervical carcinomatous lesions (85.7-100%), but cathepsin-D was very low (7.1-32%). Immunostain for CD44 showed a lower expression in invasive carcinoma with and without metastasis (50.4 and 52.2%) than in carcinoma in situ (68.0%). CD44v6 protein showed some controversy of expression between invasive carcinoma with metastasis (35.7%) without metastasis (56.5%). Staining for nm23 was observed in the high expression of invasive lesions (85.7%). TGF- 1 and C-erbB-2 protein were highly expressed, especially in the microinvasive carcinoma (81.8%, 42.8%, respectively).
Conclusions : These results suggest that CD44 and CD44v6 were not highly expressed in the invasive squamous carcinoma of the uterine cervix. However, it is notable that TGF- 1 and c-erbB-2 in the microinvasive carcinoma and nm23 in invasive carcinoma were highly expressed compared to these of the other lesions of the uterine cervix.
Key Words : Metastasis, Cervix uteri, Squamous cell carcinoma, Immunohistochemistry
Alternative Title
Early Detection of Metastasis by Immunohistochemistry in Uterine Cervical Carcinoma
Keimyung Author(s)(Kor)
박관규
권선영
장은숙
차순도
Publisher
School of Medicine
Citation
박관규 et al. (2001). 자궁경부암종에서 암 전이의 조기 발견을 위한 면역조직화학 연구. 대한병리학회지, 35(5), 391–400.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38628
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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