전립선암 및 전립선비대증에서의 bcl-2 와 p53 단백 발현

Abstract

Purpose: To investigate the expression of mutant p53 and bcl-2 oncoprotein in human benign and neoplastic prostate. Materials and Methods: The accumulation of p53 and the expression of bcl-2 were investigated immunohistochemically in paraffin-embedded tissue specimens(obtained by transurethral resection and biopsy) from 55 patients with primary prostatic cancer(mean age 69 years, range 54-86) and 47 patients with benign prostatic hyperplasia (BPH) (mean age 61 years, range 51-75). Results: Positive immunoreactivity for p53 and bcl-2 was detected in 23(41.8%) and 32(58.2%) samples of prostatic cancer tissue, respectively. There were more samples expressing p53 in prostatic cancer with a high Gleason score than in samples from cancer with low score. In samples from 47 patients with BPH, positive immunoreactivity for p53 and bcl-2 was observed in 12(25.5%) and 19(40.4%), respectively; stained cells were restricted to the basal cell layers of the gland. Conclusions: There was an association between prostatic tumor grade and the increasing expression of p53. The staining pattern of cells expressing p53 and bcl-2 may be different between prostatic cancer and BPH tissues. Key word : p53, bcl-2, Prostatic cancer, Ban prostatic cancer, Benign prostatic hyperplasia