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내분비요법저항성 전립선암에서의 Ketoconazole과 Prednisolone 복합요법의 경험

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Author(s)
이병태김천일
Keimyung Author(s)
Kim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
1998
Volume
39
Issue
10
Abstract
Purpose: Corticosteroids suppress the pituitary production of adrenocorticotropic hormone resulting in decreased adrenal steroid production, including adrenal androgens. Ketoconazole is an imidazole fungal agent that inhibit both testicular and adrenal androgenesis. Its primary mechanism of action is inhibition of a cytochrome p450 dependent step in the steroid synthesis pathway, although it has also been reported to have a direct cytotoxic effect in vitro. The effect of further adrenal androgen blockade with ketoconazole plus predinisolone was studied in 9 patients with prostatic cancer who previously progressed after standard hormone therapy.
Materials and Methods: We treated 9 patients who had hormone refractory metastatic prostate cancer(goserelin acetate, 3 cases; combined goserelin acetate and flutamide, 6 cases) with 200mg ketoconazole orally every 8 hours and 5mg prednisolone orally every 12 hours. Mean follow-up period was 6 months(1-15 months).
Results: Overall, of 8 evaluabel patients 3 had greater than a 50% decrease, 2 had stable and 3 had increase in PSA. The median duration of response was 4 months. Pain was improved in 4 patients. Ketoconazole was generally well tolerated. Toxicity was mild. Nausea with vomiting, edema and hepatotoxicity occurred in 6, 4, 1 patients, respectively. Only 1 patient was withdrawn due to possible ketoconazole-related toxicity.
Conclusions: We concluded that ketoconazole with prednisolone may be a useful treatment modality for management of patients with hormone refractory prostatic cancer. (Korean J Urol 1998; 39: 1001~5)"
Key word : Ketoconazole, Prednisolone, Hormone refractory prostate cancer
Alternative Title
Ketoconazole with Prednisolone for the Treatment of Hormone Refractory Prostate Cancer
Keimyung Author(s)(Kor)
김천일
Publisher
School of Medicine
Citation
이병태 and 김천일. (1998). 내분비요법저항성 전립선암에서의 Ketoconazole과 Prednisolone 복합요법의 경험. 대한비뇨기과학회지, 39(10), 1001–1005.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38695
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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