계명대학교 의학도서관 Repository

전립선비대증 환자에 있어서 혈청 PSA치와 경직장 초음파검사와의 상관관계 및 임상적 의의

Metadata Downloads
Author(s)
하달봉이상성박철희이성준이성문우성구
Keimyung Author(s)
Park, Choal HeeLee, Sung MunLee, Sung JoonWoo, Seong Ku
Department
Dept. of Urology (비뇨의학)
Dept. of Radiology (영상의학)
Journal Title
대한비뇨기과학회지
Issued Date
1993
Volume
34
Issue
5
Abstract
We investigated a correlation of serum prostate specific antigen(PSA) and preoperative prostatic volume measured by transrectal ultrasonography (TRUS) in 66 patients with pathologically con- firmed benign prostatic hyperplasia (BPH), as aids in the early detection of prostate cancer and in the improvement of specificity in BPH. The preoperative serum PSA value was also measured in 18 patients with pathologically confirmed prostate cancer and 15 men without prostatic disease as normal control using Tandem-R PSA radioimmunometric assay. There was a highly significant correlation between natural logarithm transformed PSA(In PSA) and non-transformed prostatic volume by linear regression analysis(r =0.6668, p<0.0001). Given above data, we determined a volume adjusted 95th percentile upper confidence limit for n PSA as an appropriate cutoff between normal and abnormal PSA value, according to prostatic volume in BPH. In the patients with BPH and prostate cancer, sensitivity, specificity, diagnostic accuracy and positive predictive value were 94%, 72%, 68% and 48%, respectively. A statistical results by the volume-adjusted cutoff for in PSA was similar to that at 10ng/ml as cutoff for PSA value. Above 40ml in prostatic volume, however, a false positive rate was decreased in inverse proportion to prostatic volume in BPH. In summary, the prostatic volume must be considered in BPH patients with elevated serum PSA value, negative digital rectal examination and negative TRUS of prostate. And when the volume adjusted PSA cutoff is clinically applied to BPH patients for the early detection of prostate cancer, we thought that the false positive rate can be decreased in BPH patients.
Key word : PSA, Proslatic volume, BPH, Prostate cancer.
Alternative Title
The Correlation of Serum Prostate Specific Antigen(PSA) and Prostatic Volume Measured by Transrectal Ultrasonography in the Diagnosis of Benign Prostatic Hyperplasia
Keimyung Author(s)(Kor)
박철희
이성준
이성문
우성구
Publisher
School of Medicine
Citation
하달봉 et al. (1993). 전립선비대증 환자에 있어서 혈청 PSA치와 경직장 초음파검사와의 상관관계 및 임상적 의의. 대한비뇨기과학회지, 34(5), 821–827.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38697
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.