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Chlormadinone Acetate가 전립선비대증 환자의 혈청 전립선특이항원치에 미치는 영향

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Author(s)
조진선이경섭김법완김세웅김청수노충희류현열박광성박동수박재신박종관서일영오태희이상은정병하정세일정재일정희창조인래김천일
Keimyung Author(s)
Kim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
2006
Volume
47
Issue
4
Abstract
Purpose: Chlormadinone acetate(CMA) therapy for benign prostatic hyperplasia(BPH) may lower the serum prostate specific antigen(PSA) level. However, little is known about the effect of CMA on the total or free serum PSA levels of PSA. Such information would be important since PSA testing is useful for prostate cancer screening. Thus, we prospectively studied the effect of CMA therapy on the total and free serum PSA levels. Materials and Methods: The patients with lower urinary tract symptoms (LUTS) and BPH who were aged over 50 years were treated with 50mg CMA for 6 months. Men with a PSA level greater than 10ng/ml were excluded to reduce the likelihood of including cases of occult prostate cancer. Those with suspicious findings on the digital rectal examination and serum PSA testing were biopsied to rule out prostate cancer. α- blocking agents were permitted to treat the men with LUTS. Serum levels of the total and free PSA were measured at the study baseline and after approximately 3 and 6 months. The prostate volume(PV) was assessed by transrectal ultrasonography. Results: The analysis included 170 patients with a mean age of 67.9 years, a baseline PV of 47.3ml and a baseline total PSA of 4.1ng/ml. The total PSA levels declined from 4.1ng/ml at baseline to 2.0ng/ml after 6 months of treatment(50.7% decrease, p<0.01). The mean percent free PSA(21% to 22% at baseline) was not significantly altered by CMA treatment. The PSA levels and PV at baseline did not affect the rate of decline of PSA. Conclusions: The total PSA serum levels decreased by an average of 50% during CMA therapy, but the percent free PSA did not change significantly. This information is potentially useful in the interpretation of the PSA data that's used for early detection of prostate cancer in the men receiving CMA. (Korean J Urol 2006;47:368-371)
Key word : Chlormadinone acetate, Prostate-specific antigen, Benign prostatic hyperplasia
Alternative Title
The Influence of Chlormadinone Acetate on the Total and Free Serum Prostate Specific Antigen Levels in Men with Benign Prostatic Hyperplasia
Keimyung Author(s)(Kor)
김천일
Publisher
School of Medicine
Citation
조진선 et al. (2006). Chlormadinone Acetate가 전립선비대증 환자의 혈청 전립선특이항원치에 미치는 영향. 대한비뇨기과학회지, 47(4), 368–371. doi: 10.4111/kju.2006.47.4.368
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2006.47.4.368
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38699
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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