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국소 신세포암에서 종양의 크기에 의한 T1병기의 재분류

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Author(s)
김동일박철희김천일
Keimyung Author(s)
Park, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
2005
Volume
46
Issue
1
Abstract
Purpose: New cutoffs have recently been proposed for restaging T1 diseases, as the prognostic differences were more prominent with these cutoffs. The validity of these cutoffs was evaluated by restaging patients with localized renal cell carcinomas (T1-2N0M0) using the new cutoffs (2.5, 3, 4, 5, 7 and 10cm, and capsule invasion).
Materials and Methods: 99 patients with pathologically confirmed T1 and T2 carcinomas, who had undergone radical nephrectomy between June 1990 and March 2003, were retrospectively reviewed. The study group comprised of 61 men and 38 women, with a mean age of 56.2, ranging from 21 to 78 years. The mean follow up length was 69, ranging from 8 to 162 months. The patients were divided into two groups using the new cutoff points (2.5, 3, 4, 5, 7 and 10cm, and capsule invasion). The survival curves were calculated by the Kaplan-Meier method for each cutoff point, with Log-rank tests used to compare the values of the new cutoff points.
Results: Statistically significant cancer specific survivals at 4, 5 and 7cm cutoffs, with a 5cm cutoff point, were used to maximize the differences in the cancer specific survivals. The 4cm cutoff point was the only statistically significant cutoff value for disease free survivals. Capsule invasion was not a statistically significant cutoff value.
Conclusions: A 5cm cutoff point was proposed to divide the T1N0M0 classification into T1a and T1b subclasses. Patients with localized renal cell carcinomas larger than 4cm in size were considered for radical nephrectomy rather than a partial nephrectomy in relation to a local recurrence. (Korean J Urol 2005;46:43-48)
Alternative Title
Restaging of the Stage T1 Localized Renal Cell Carcinomas Using New Cut-off Value
Keimyung Author(s)(Kor)
박철희
김천일
Publisher
School of Medicine
Citation
김동일 et al. (2005). 국소 신세포암에서 종양의 크기에 의한 T1병기의 재분류. 대한비뇨기과학회지, 46(1), 43–48.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38715
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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