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국소성 신세포암 환자에서 독립적인 예후인자로서 핵분화도의 의의

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Author(s)
하지용장혁수김천일
Keimyung Author(s)
Ha, Ji YongChang, Hyuk SooKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
2007
Volume
48
Issue
5
Abstract
Purpose: As the number of patients with localized renal cell carcinoma has increased, there are conflicting reports on the nuclear grade as a prognostic factor. The aim of this study was to evaluate the significance of the nuclear grade as a prognostic factor.
Materials and Methods: We retrospectively enrolled 172 patients with localized renal cell carcinoma and who underwent radical nephrectomy. The patients were staged according to the 1997 TNM stage and the Fuhrman grading. The survival rate was analyzed by the Kaplan-Meier method. Multivariate analysis was performed using the Cox proportional hazard model.
Results: The overall 1- , 5- and 10-year survival rates were 98.1, 72.5 and 68.4%, respectively. The 5-year survival rates for grades I, II, III and IV were 100, 92.6, 85.0 and 60.9%, respectively (p<0.0001). According to the Fuhrman grade in each T stage, 1) for patients with pT1b, the 5-year survival rates were 100, 85.0, 85.71 and 33.3% for patients with grade I, II, III and IV, respectively (p=0.002). 2) for patients with pT2, the 5-year survival rates were 100, 92.3, 60.0 and 25.0% for patients with grade I, II, III and IV, respectively (p<0.0001). A comparison of the survival curves by the Fuhrman grade showed a statistically significant difference.
Conclusions: The Fuhrman grade is an important prognostic factor for patients with localized renal cell carcinoma. A high nuclear grade tends to have metastatic potential and a poor prognosis. This group of patients with a high nuclear grade must be followed up more closely. Determining the pathologic stage along with using the Fuhrman grade-based surveillance protocols are a logical approach to follow-up. (Korean J Urol 2007;48:471-476)
Alternative Title
Significance of the Nuclear Grade as a Prognostic Factor for Patients with Localized Renal Cell Carcinoma
Keimyung Author(s)(Kor)
하지용
장혁수
김천일
Publisher
School of Medicine
Citation
하지용 et al. (2007). 국소성 신세포암 환자에서 독립적인 예후인자로서 핵분화도의 의의. 대한비뇨기과학회지, 48(5), 471–476. doi: 10.4111/kju.2007.48.5.471
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2007.48.5.471
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38716
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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