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국소 진행성 방광암에 대한 보조적 M-VAC (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) 항암화학요법의 효과

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Author(s)
이병태박철희김천일
Keimyung Author(s)
Park, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
1996
Volume
37
Issue
9
Abstract
The efficacy of adjuvant chemotherapy in locally advanced bladder cancer is still debated. Between March 1986 and February 1995, we retrospectively reviewed 25 patients with invasive, pathological stage P3b, P4 or N1 and M0 transitional cell carcinoma of the bladder who were treated with radical cystectomy alone (control group), adjuvant M-VAC chemotherapy after the surgery. The mean follow up period was 28 months. There were 13 patients in the control group and 12 in adjuvant chemotherapy group. The pathological stage distributions were P3b in 9 patients (5 in control group, 4 in chemotherapy group), P4 in 9 patients (5 in control group, 4 in chemotherapy group), N1 in 7 patients (3 in control group, 4 in chemotherapy group). Median survival times were 27 months in adjuvant chemotherapy group compared to 15 months in the control group, however they were not related statistically each other (P>0.05). The 2-year survival rates were 38% in control group, 70% in adjuvant chemotherapy group but they were not related statistically each other (P>0.05). We are not able to confirm the efficacy of adjuvant M-VAC chemotherapy in locally advanced bladder cancer. However adjuvant chemotherapy seems to have some beneficial effect. Controlled prospective clinical trials with large number of patients would be needed to assess the real efficacy of adjuvant M-VAC chemotherapy.
Key word : Adjuvant chemotherapy, Locally advanced bladder cancer
Alternative Title
Adjuvant M-VAC Chemotherapy in Locally Advanced Bladder Cancer
Keimyung Author(s)(Kor)
박철희
김천일
Publisher
School of Medicine
Citation
이병태 et al. (1996). 국소 진행성 방광암에 대한 보조적 M-VAC (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) 항암화학요법의 효과. 대한비뇨기과학회지, 37(9), 967–973.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38718
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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