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방광암의 c-myc 및 c-Ha-ras 암유전자의 유전표현

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Author(s)
박철희서민호이성준Choal Hee ParkMin Ho SuhSung Choon Lee
Keimyung Author(s)
Suh, Min HoPark, Choal HeeLee, Sung Joon
Department
Dept. of Urology (비뇨의학)
Dept. of Microbiology (미생물학)
Journal Title
대한비뇨기과학회지
Issued Date
1992
Volume
33
Issue
2
Abstract
In order to elucidate the c-myc and c-Ha-ras oncogenes expressions in human bladder cancers. we examined twelve bladder cancer tissues. two normal bladder tissues and two blood specimens with Southern. Northern and Slot blot hybridizations. In Southern blot all of the specimens showed 14 kilobase(Kb) c-myc band and 6.6kb c-Ha-ras band. No significant amplifications were observed in the levels of c-myc and c-Ha-ras DNA in cancer tissues. In Northern and slot blot, four bladder cancer tissues showed increased expression of c-myc RNA. No significant differences were observed in the levels of c-Ha-ras RNA expression between cancer tissues and normals. In conclusion. these findings support that quantitative increase in c-myc expression plays its role in the development of bladder cancers. Further studies about c-Ha-ras point mutation analysis and P21 ras protein analysis should be done to identify the role or c-Ha-ras in bladder tumorigenesis.
Key word : Bladder cancer, C-myc, C-Ha-ras, Oncogene
Alternative Title
Expression of c-myc and c-Ha-ras Oncogenes in Human Bladder Cancer
Keimyung Author(s)(Kor)
박철희
이성준
서민호
Publisher
School of Medicine
Citation
박철희 et al. (1992). 방광암의 c-myc 및 c-Ha-ras 암유전자의 유전표현. 대한비뇨기과학회지, 33(2), 206–212.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38728
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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