비전립선암군에서 혈청전립선특이항원(PSA)치의 상승에 영향을 미치는 인자

Abstract

Elevations of serum PSA concentrations have been widely reported due to prostatic cancer, but other causes have not been formally characterized or quantified. So that, we evaluated the causes of elevated serum PSA concentrations in men whose prostate biopsy showed no cancer. The effects of prostate volume, inflammation, echogenecity on ultrasound and calculi were examined in 43 men that serum PSA concentrations greater than 4.0 ng/ml with negative biopsy. These men were compared with 16 men who had suspicious rectal examinations, negative biopsy and serum PSA concentrations of 4.0 ng/ml. or less. Prostate volume (22.5%, p<0.005) and inflammation (3%, p<0.05) were significantly associated with elevated serum PSA concentrations (>4.0 ng/ml) than control group(=<4.0 ng/ml) and age, echogenecity on ultrasound and calculi were statistically less significant (p>=0.05). In summary, prostate volume and inflammation were the most important factors contributing to increase serum PSA concentration in men that clinically undetectable prostatic cancer. Key word : Prostate volume, Inflammation