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빈뇨와 만성골반통을 호소하는 환자에서 Amitriptyline의 효과

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Author(s)
이동형박철희김천일Dong Hyoung LeeChoal Hee ParkChun Il Kim
Keimyung Author(s)
Park, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
2001
Volume
42
Issue
6
Abstract
Purpose: We evaluated the effects of amitriptyline in patients with urinary frequency or pelvic pain syndrome and compared with propiverine hydrochloride (BUP-4􂃕) and diazepam (Valium􂃕).
Materials and Methods: One-hundred and sixty-eight patients with urinary frequency or pain were included and 38 out of 168 patients were lost to follow up. The patients with interstitial cystitis, UTI and neurogenic bladder were excluded. Amitriptyline group were instructed to take 25mg to 75mg of amitriptyline before bed. Propiverine hydrochloride and diazepam group were instructed to take 20mg, 4-6mg before bed, respectively. The clinical effects and side effects were evaluated after 4 weeks of medication.
Results: In the amitriptyline group, 73.1% in 78 patients with frequency, 68.3% in 60 pain, 65.6% in 32 nocturia, 53.8% in 26 weak urinary stream, 53.8% in 13 dysuria, 72.7% in 11 urgency showed symptom improvement. Urinary frequency and pain score were significantly decreased in the amitriptyline group. In the propiverine hydrochloride group, 66.7% in 21 patients with frequency, 38.8% in 18 pain showed symptom improvement. In the diazepam group, 37.5% in 24 patients with frequency, 31.3% in 16 pain showed symptom improvement. Side effects of amitriptyline had appeared in 24 (27.6%) out of 87 patients; 17 cases of dry mouth, 10 drowsiness, 2 agitation, 2 nausea, 1 constipation and 1 skin rash.
Conclusions: Amitriptyline is useful in vague voiding symptoms especially in urinary frequency and chronic pelvic pain syndrome. It is equally effective in both men and women. Side effects are minimal and tolerable. A double-blind placebo-controlled trial is necessary for general acceptance in the future. (Korean J Urol 2001; 42:615-620)
Alternative Title
The Clinical Effects of Amitriptyline in Patients with Urinary Frequency and Chronic Pelvic Pain Syndrome
Keimyung Author(s)(Kor)
박철희
김천일
Publisher
School of Medicine
Citation
이동형 et al. (2001). 빈뇨와 만성골반통을 호소하는 환자에서 Amitriptyline의 효과. 대한비뇨기과학회지, 42(6), 615–620.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38740
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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