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신세포암에 대한 근치적 수술 후 무재발 생존의 예후 인자 및 예측 노모그램

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Author(s)
Chun Il KimJun CheonKyung Seop LeeSe Il ChungMoon Kee ChungHan Yong ChoiHyun Moo LeeSe Joong KimSung Joon HongJae il ChungSang Min YoonYong Goo LeeHyung Jin KimHongsik KimWun Jae KimSoo Bang RyuHanjong AhnChoung Soo Kim송채린박종연이무송정한조용현김법완장성구김천일천준이경섭정세일정문기최한용이현무김세중홍성준정재일윤상민이영구김형진김홍식김원재류수방안한종김청수Cheryn SongJong Yeon ParkMoo Song LeeHan ChungYong Hyun ChoBup Wan KimSung Goo Chang
Keimyung Author(s)
Kim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
2006
Volume
47
Issue
9
Abstract
Purpose: This multiinstitutional study was to investigate the accuracy of the Kattan nomograms for the prediction of recurrence after definitive surgery for renal cell carcinoma (RCC) in Korean patients and develop a nomogram revised to complement the shortcomings.
Materials and Methods: Clinical and pathological data of 1,866 patients with RCC who had been followed for at least 2 years after surgery in each participating institutes were reviewed as well as evidence of disease recurrence, defined to include local recurrence and distant metastasis. Accuracy of the Kattan nomograms' predictability in tumors 7cm or less was tested by calculating the area under the receiver-operating characteristics curve (AUC) and actuarial recurrence-free survival by Kaplan-Meier method. We used the Cox proportional hazard analysis to identify significant variables and develop prediction nomogram, and internally validated by bootstrapping method. Mean follow-up was 56.5 months (24-184).
Results: Recurrence occurred in 12.5% of the patients and correlated with the pathological stage, with 4.3%, 7.9%, 15.0%, 22.6%, 38.4%, 58.3% for stages T1a, T1b, T2, T3a, T3b/c and T4, respectively (p<0.001). The AUC of the Kattan nomograms was 0.276. Factors significantly predictive of recurrence were T stage (p<0.0001), presentation (p=0.006), preoperative hemoglobin (p=0.023) and gender (p=0.032). Actuarial 60-month recurrencefree survival was 87.9% and using the prognostic factors, nomogram predicting 60-month recurrence-free survival was constructed.
Conclusions: Korean nomogram complementing the preexisting nomograms for the prediction of recurrence-free survival after definitive surgery for RCC has been constructed, which may be useful in patient prognostication, counseling and follow-up planning. (Korean J Urol 2006;47:963-967)
Alternative Title
Korean Nomogram for the Prediction of Recurrence-free Survival after Definitive Surgery for Renal Cell Carcinoma
Keimyung Author(s)(Kor)
김천일
Publisher
School of Medicine
Citation
Chun Il Kim et al. (2006). 신세포암에 대한 근치적 수술 후 무재발 생존의 예후 인자 및 예측 노모그램. 대한비뇨기과학회지, 47(9), 963–967. doi: 10.4111/kju.2006.47.9.963
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2006.47.9.963
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38761
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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