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야간뇨를 호소하는 전립선비대증 환자에서 Loxoprofen Sodium의 효과

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Author(s)
장혁수김병건손지철박철희김천일Hyuk Soo ChangByoung Kun KimJi Choal SohnChoal Hee ParkChun Il Kim
Keimyung Author(s)
Chang, Hyuk SooPark, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
2007
Volume
48
Issue
2
Abstract
Purpose: The effectiveness of Loxoprofen sodium, a non-steroidal anti-inflammatory drug (NSAID), on the nocturia in patients with benign prostatic hyperplasia (BPH), not responding to anticholinergics or hypnotics, as well as alpha-blockers and 5 alpha reductase inhibitors, were investigated.
Materials and Methods: Between October 2004 and June 2005, 150 BPH patients with 2 or more episodes of nocturia, despite treatments with anticholinergics or hypnotics, were enrolled in this study. Loxoprofen, 60mg/day, was orally administered prior to sleeping for 2 weeks. The number of episodes of nocturia was assessed before and after treatment according to baseline number of episodes of nocturia, age distribution, prostate volume and previous nocturia treatment.
Results: The number of nocturia episodes decreased by at least 1 in 74.7% (112/150) of patients, and decreased by 2 or more, 1 and were unchanged or increased were 48.0, 26.7 and 25.3% of patients, respectively. In baseline nocturia ≥6 group, the nocturia decreased by 1 or more in 85.0%. Treatment-emergent adverse events, including gastric discomfort (12 patients, 8.0%), weak urinary stream (5 patients, 3.3%) and leg edema (2 patients, 1.3%), occurred in 19 of the 150 (12.7%) patients. There were no withdrawals resulting from adverse events.
Conclusions: Loxoprofen can be effectively combined as a treatment option for patients with BPH complaining of unresolved nocturia. However, studies on the mechanism of action, long term effectiveness and adverse events of Loxoprofen are necessary. (Korean J Urol 2007;48:195-198)
Alternative Title
Effectiveness of Loxoprofen Sodium on Nocturia in Patients with Benign Prostatic Hyperplasia
Keimyung Author(s)(Kor)
장혁수
박철희
김천일
Publisher
School of Medicine
Citation
장혁수 et al. (2007). 야간뇨를 호소하는 전립선비대증 환자에서 Loxoprofen Sodium의 효과. 대한비뇨기과학회지, 48(2), 195–198. doi: 10.4111/kju.2007.48.2.195
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2007.48.2.195
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38765
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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