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전립선비대증 환자에서 큰 전립선용적의 기준

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Author(s)
조진선김천일성도환김홍섭김영식김세중조인래전상현이동현양원재최영득홍성준주영수송윤섭김선일정병하Jin Seon ChoChun Il KimDo Hwan SeongHong Sup KimYoung Sik KimSe Joong KimIn Rae ChoSang Hyeon CheonDong Hyeon LeeWon Jae YangYoung Deuk ChoiSung Joon HongYoung-Su JuYun Seob SongSun Il KimByung Ha Chung
Keimyung Author(s)
Kim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
2005
Volume
46
Issue
12
Abstract
Purpose: Prostate volume (PV) is a key predictor of both the progression and response to medical therapy for the patients suffering with benign prostatic hyperplasia (BPH). 5 alpha reductase inhibitors are effective for the patients with a large PV. Prostate-specific antigen (PSA) has been predominantly studied as a proxy marker to estimate the PV in a Caucasian patient population. If the PV of Korean men is smaller than that of Caucasian men, then the PSA-PV may be different for Korean men as compared with the other races. We evaluated the optimal PSA cut-off point to predict the response to 5 alpha reductase inhibitors with using Korean PSA-PV equations. Materials and Methods: Patients aged between 50 and 79 years with lower urinary tract symptoms and BPH were enrolled in this multicenter study from 1999 to 2004. IPSS, PSA, uroflowmetry and TRUS measurements were performed on all the patients. We performed the computations using the logarithms of the PSA and PV. PV and PSA have an age-dependent log-linear relationship. The prediction curve was given by PV(55)=28.84x PSA0.208, PV(65)=30.36xPSA0.245, and PV(75)=30.23xPSA0.280. If a PV of 40ml was applied to these equations, then the PSA values were obtained for men in their 50s, 60s and 70s, respectively. If these PSA values were again applied to the Roehrborn's equations, then the PVs of Korean men were obtained. Receiver operating characteristic (ROC) curves were constructed to evaluate the ability of the serum PSA to predict the threshold PV in the men suffering with BPH. Results: The analysis included 5,716 patients with a mean age of 64.3 years, a mean baseline PV of 36.9ml and a baseline PSA value of 2.4ng/ml. The approximate cut-off PV for the Korean men was 35ml. The ROC curve analysis revealed that PSA had good predictive value for the PV cut-off point (35ml) from the Korean PSA-PV equations. The approximate agespecific criteria for detecting Korean men with a PV exceeding 35ml are a PSA >1.2ng/ml, >1.6ng/m, and >2.0ng/ml for the men with BPH who are in their 50s, 60s and 70s, respectively. Conclusions: The PSA-PV relationship in Korean men shows that Korean men have a lower PSA and a smaller PV than Caucasians. The PV of Korean men corresponding to a PV of 40ml for Caucasians was approximately 35ml. (Korean J Urol 2005;46:1246-1250)
Key Words: Benign prostatic hyperplasia, Prostate-specific antigen, Prostate volume
Alternative Title
Cut-off Point of Large Prostate Volume for the Patients
with Benign Prostatic Hyperplasia
Keimyung Author(s)(Kor)
김천일
Publisher
School of Medicine
Citation
조진선 et al. (2005). 전립선비대증 환자에서 큰 전립선용적의 기준. 대한비뇨기과학회지, 46(12), 1246–1250.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38788
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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